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Flumexadol
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Catalog No. T11302Cas No. 30914-89-7
Flumexadol is a selective 5-HT2C receptor agonist with an affinity (Ki) of 25 nM for the (+)-enantiomer and exhibits 40-fold selectivity over the 5-HT2A receptor. It is an orally active, non-narcotic analgesic.
Flumexadol
🥰Excellent
Catalog No. T11302Cas No. 30914-89-7
Flumexadol is a selective 5-HT2C receptor agonist with an affinity (Ki) of 25 nM for the (+)-enantiomer and exhibits 40-fold selectivity over the 5-HT2A receptor. It is an orally active, non-narcotic analgesic.
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Product Introduction
Bioactivity
Chemical Properties
| Description | Flumexadol is a selective 5-HT2C receptor agonist with an affinity (Ki) of 25 nM for the (+)-enantiomer and exhibits 40-fold selectivity over the 5-HT2A receptor. It is an orally active, non-narcotic analgesic. |
| Targets&IC50 | 5-HT2C receptor:25 nM (ki) |
| In vivo | In rats and dogs dosed with 14C-Flumexadol (CERM1841), the 14C is primarily excreted in the urine. The 14C eliminated in the feces of dogs is significantly higher than that for rats. Conjugated metabolites, mostly glucuronides, accounted for the majority of the urinary radioactivity in both species. Biotransformation products are predominantly acids in both species, followed by substantial amounts of basic metabolites, with minimal neutral substances. The major urinary metabolites in rats are 3-trifluoromethylbenzoic acid and 3-trifluoromethylhippuric acid, whereas in dogs, the major metabolite is 3-trifluoromethylmandelic acid, along with the benzoic acid and its conjugate. The basic products identified in the urine of both species are unchanged drug and 1-amino-2-hydroxy-2-(3-trifluoromethylphenyl)ethane, with the former predominating. |
| Molecular Weight | 231.21 |
| Formula | C11H12F3NO |
| Cas No. | 30914-89-7 |
| Relative Density. | 1.2081 g/cm3 (Estimated) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 100 mg/mL (432.51 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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