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Glimepiride
🥰Excellent
Catalog No. T0127Cas No. 93479-97-1
Alias HOE-490, Glimperide
Glimepiride (HOE-490) is a long-acting, third-generation sulfonylurea with hypoglycemic activity.
Glimepiride
🥰Excellent
Purity: 99.97%
Catalog No. T0127Alias HOE-490, GlimperideCas No. 93479-97-1
Glimepiride (HOE-490) is a long-acting, third-generation sulfonylurea with hypoglycemic activity.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 200 mg | $33 | In Stock | |
| 500 mg | $54 | In Stock | |
| 1 g | $89 | In Stock | |
| 5 g | $384 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $50 | In Stock |
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Purity:99.97%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Glimepiride (HOE-490) is a long-acting, third-generation sulfonylurea with hypoglycemic activity. |
| Targets&IC50 | SUR2B:7.3 nM, SUR1:3 nM, SUR2A:5.4 nM |
| In vitro | In both normal and insulin-resistant adipocytes, as well as in myocytes, Glimepiride effectively stimulates glucose transport, and the synthesis of lipids and glycogen. In cardiomyocytes, Glimepiride (IC50=6.8 nM) inhibits the pinacidil-activated whole-cell K(ATP) current. Additionally, in HEK 293 cells, Glimepiride (IC50=6.2 nM) blocks the K(ATP) channels formed by the co-expression of Kir6.2/SUR2A subunits. |
| In vivo | Within diabetic rats, Glimepiride has been shown to decrease the incidence of sperm abnormalities, enhance sperm count, and bolster antioxidant capacity. |
| Alias | HOE-490, Glimperide |
| Molecular Weight | 490.62 |
| Formula | C24H34N4O5S |
| Cas No. | 93479-97-1 |
| Smiles | C(NCCC1=CC=C(S(NC(N[C@H]2CC[C@H](C)CC2)=O)(=O)=O)C=C1)(=O)N3C(=O)C(CC)=C(C)C3 |
| Relative Density. | 1.29 g/cm3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 16.67 mg/mL (33.97 mM)  | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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