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GNE-493
🥰Excellent
Catalog No. T7166Cas No. 1033735-94-2
GNE-493 is potent, selective, and orally available PI3K and mTOR inhibitor with potential anticancer activity.IC50s of 3.4 nM, 12 nM, 16 nM, 16 nM and 32 nM for PI3Kα, PI3Kβ, PI3Kδ, PI3Kγ and mTOR,respectively.
GNE-493
🥰Excellent
Purity: 98%
Catalog No. T7166Cas No. 1033735-94-2
GNE-493 is potent, selective, and orally available PI3K and mTOR inhibitor with potential anticancer activity.IC50s of 3.4 nM, 12 nM, 16 nM, 16 nM and 32 nM for PI3Kα, PI3Kβ, PI3Kδ, PI3Kγ and mTOR,respectively.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $41 | In Stock | |
| 5 mg | $106 | In Stock | |
| 10 mg | $172 | In Stock | |
| 25 mg | $363 | In Stock | |
| 50 mg | $579 | In Stock | |
| 100 mg | $892 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $117 | In Stock |
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CitedSelect Batch
Purity:98%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | GNE-493 is potent, selective, and orally available PI3K and mTOR inhibitor with potential anticancer activity.IC50s of 3.4 nM, 12 nM, 16 nM, 16 nM and 32 nM for PI3Kα, PI3Kβ, PI3Kδ, PI3Kγ and mTOR,respectively. |
| Targets&IC50 | PI3Kγ:16 nM , mTOR:32 nM, PI3Kα:3.4 nM , PI3Kδ:16 nM , PI3Kβ:12 nM |
| In vivo | GNE-493 was tested in a human MCF7.1 breast cancer xenograft model with a PI3Kα activating mutation. Mice with xenografts received a daily oral dose of 10 mg/kg of GNE-493 for 21 continuous days. Comparable to results in the PC3 prostate cancer model, this treatment led to a 73% inhibition of tumor growth by day 21 compared to control. With similar drug exposure levels, GNE-493 demonstrated equivalent suppression of the PI3K pathway and, thus, comparable efficacy against MCF7.1 breast tumors. |
| Molecular Weight | 372.44 |
| Formula | C17H20N6O2S |
| Cas No. | 1033735-94-2 |
| Smiles | CC(C)(O)c1cc2nc(nc(N3CCOCC3)c2s1)-c1cnc(N)nc1 |
| Relative Density. | 1.408 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 45 mg/mL (120.82 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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