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GNE-493

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Purity:98%

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COA HNMR

GNE-493

Catalog No. T7166Cas No. 1033735-94-2

GNE-493 is potent, selective, and orally available PI3K and mTOR inhibitor with potential anticancer activity.IC50s of 3.4 nM, 12 nM, 16 nM, 16 nM and 32 nM for PI3Kα, PI3Kβ, PI3Kδ, PI3Kγ and mTOR,respectively.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Pack Size	Price	Availability
1 mg	$45	In Stock
5 mg	$106	In Stock
10 mg	$172	In Stock
25 mg	$363	In Stock
50 mg	$579	In Stock
100 mg	$892	In Stock
1 mL x 10 mM (in DMSO)	$117	In Stock

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Product Introduction

Bioactivity

Description

In vivo

GNE-493 was tested in a human MCF7.1 breast cancer xenograft model with a PI3Kα activating mutation. Mice with xenografts received a daily oral dose of 10 mg/kg of GNE-493 for 21 continuous days. Comparable to results in the PC3 prostate cancer model, this treatment led to a 73% inhibition of tumor growth by day 21 compared to control. With similar drug exposure levels, GNE-493 demonstrated equivalent suppression of the PI3K pathway and, thus, comparable efficacy against MCF7.1 breast tumors.

Chemical Properties

Molecular Weight	372.44
Formula	C17H20N6O2S
Cas No.	1033735-94-2

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 45 mg/mL (120.82 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6850 mL	13.4250 mL	26.8500 mL	134.2498 mL
5 mM	0.5370 mL	2.6850 mL	5.3700 mL	26.8500 mL
10 mM	0.2685 mL	1.3425 mL	2.6850 mL	13.4250 mL
20 mM	0.1342 mL	0.6712 mL	1.3425 mL	6.7125 mL
50 mM	0.0537 mL	0.2685 mL	0.5370 mL	2.6850 mL
100 mM	0.0268 mL	0.1342 mL	0.2685 mL	1.3425 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

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