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GNE-900
🥰Excellent
Catalog No. T71259Cas No. 1200126-26-6
Alias GNE900, GNE 900
GNE-900 is an ATP-competitive ChK1 inhibitor with selective and oral activity.GNE-900 inhibits ChKl and ChK2 with IC50 values of 0.0011 and 1.5 µM, respectively.GNE-900 enhances DNA damage and induces apoptosis. GNE-900 has antitumor activity.
GNE-900
🥰Excellent
Purity: 97.18%
Catalog No. T71259Alias GNE900, GNE 900Cas No. 1200126-26-6
GNE-900 is an ATP-competitive ChK1 inhibitor with selective and oral activity.GNE-900 inhibits ChKl and ChK2 with IC50 values of 0.0011 and 1.5 µM, respectively.GNE-900 enhances DNA damage and induces apoptosis. GNE-900 has antitumor activity.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $58 | In Stock | |
| 5 mg | $139 | In Stock | |
| 10 mg | $223 | In Stock | |
| 25 mg | $396 | In Stock | |
| 50 mg | $595 | In Stock | |
| 100 mg | $913 | In Stock |
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Purity:97.18%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | GNE-900 is an ATP-competitive ChK1 inhibitor with selective and oral activity.GNE-900 inhibits ChKl and ChK2 with IC50 values of 0.0011 and 1.5 µM, respectively.GNE-900 enhances DNA damage and induces apoptosis. GNE-900 has antitumor activity. |
| Targets&IC50 | Chk2:1.5 μM, Chk1:0.0011 μM |
| In vitro | GNE-900 (1 µM; 1-48 h; HT-29 cells) induces apoptosis and enhances cleaved PARP expression when combined with gemcitabine (50 nM) in HT-29 cells.[1] |
| In vivo | GNE-900 (2.5-40 mg/kg, p.o., once; Sprague-Dawley rats) combined with gemcitabine (120 mg/kg) reduced tumor volume and increased DNA damage and γ-H2AX expression levels in rats.[1] |
| Alias | GNE900, GNE 900 |
| Molecular Weight | 367.45 |
| Formula | C23H21N5 |
| Cas No. | 1200126-26-6 |
| Smiles | C(#N)C=1C=C2C=3C(NC2=CN1)=NC=C(C3)C4=CC=C(CN5CCCCC5)C=C4 |
Storage & Solubility Information
| Storage | store at low temperature,keep away from direct sunlight | Shipping with blue ice. | ||||||||||||||||||||
| Solubility Information | DMSO: 3.85 mg/mL (10.47 mM), Sonication is recommended.  | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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