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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $67 | In Stock | |
5 mg | $163 | In Stock | |
10 mg | $289 | In Stock | |
25 mg | $487 | In Stock | |
50 mg | $696 | In Stock | |
100 mg | $987 | In Stock |
Description | GNE-900 is an ATP-competitive ChK1 inhibitor with selective and oral activity.GNE-900 inhibits ChKl and ChK2 with IC50 values of 0.0011 and 1.5 µM, respectively.GNE-900 enhances DNA damage and induces apoptosis. GNE-900 has antitumor activity. |
In vitro | GNE-900 (1 µM; 1-48 h; HT-29 cells) induces apoptosis and increases expression of cleaved PARP when combined with gemcitabine (50 nM) in HT-29 cells.[1] |
In vivo | GNE-900 (2.5-40 mg/kg; p.o.; once; Sprague-Dawley rats) combined with gemcitabine (120 mg/kg) reduced tumor volume and increased DNA damage and γ-H2AX expression levels in rats.[1] |
Alias | GNE900, GNE 900 |
Molecular Weight | 367.45 |
Formula | C23H21N5 |
Cas No. | 1200126-26-6 |
Storage | store at low temperature,keep away from direct sunlight Powder: -20°C for 3 years | In solvent: -80°C for 1 year | ||||||||||||||||||||
Solubility Information | DMSO: 3.85 mg/mL (10.47 mM) ![]() | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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