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GSK717

Catalog No. T38361 CAS 1595278-21-9

GSK717 is a potent and selective inhibitor of nucleotide-binding oligomerization domain 2 (NOD2). GSK717 blocks synergy between NOD2 and TLR2. GSK717 does not affect NOD1, TNFR1 and TLR2-mediated responses.

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GSK717, CAS 1595278-21-9

Pack Size	Availability	Price/USD
1 mg	In stock	$ 41.00
2 mg	In stock	$ 59.00
5 mg	In stock	$ 97.00
10 mg	In stock	$ 147.00
25 mg	In stock	$ 269.00
50 mg	In stock	$ 452.00
1 mL * 10 mM (in DMSO)	In stock	$ 97.00

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Purity: 99.01%

Biological Description

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Description	GSK717 is a potent and selective inhibitor of nucleotide-binding oligomerization domain 2 (NOD2). GSK717 blocks synergy between NOD2 and TLR2. GSK717 does not affect NOD1, TNFR1 and TLR2-mediated responses.
In vitro	GSK717 (5 μM) inhibits the release of IL-8, IL-6, TNFα and IL-1β in primary human monocytes stimulated with MDP. GSK717 inhibits muramyl dipeptide (MDP)-induced NOD2-mediated signaling, with an IC50 of 400 nM for MDP-stimulated IL-8 secretion in HEK293/hNOD2 cells[1].

Molecular Weight	452.55
Formula	C28H28N4O2
CAS No.	1595278-21-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 250 mg/mL (552.43 mM)

References and Literature

1. Rickard DJ, et al. Identification of benzimidazole diamides as selective inhibitors of the nucleotide-binding oligomerization domain 2 (NOD2) signaling pathway. PLoS One. 2013;8(8):e69619. Published 2013 Aug 1.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Immunology/Inflammation Compound Library NF-κB Signaling Compound Library Anti-Prostate Cancer Compound Library Anti-Liver Cancer Compound Library Anti-Breast Cancer Compound Library Pyroptosis Compound Library Bioactive Compounds Library Max Bioactive Compound Library Anti-Cancer Compound Library

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Keywords

GSK717 1595278-21-9 Immunology/Inflammation NF-Κb NOD IL Receptor GSK 717 immune inhibit Inhibitor GSK-717 NOD2-TLR2 pro-inflammatory MDP-stimulated NOD-like Receptor (NLR) responses cytokines synergy inhibitor

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