Shopping Cart
- Remove All
Your shopping cart is currently empty
HeE1-2Tyr
🥰Excellent
Catalog No. T9618Cas No. 2245195-67-7
HeE1-2Tyr, a pyridobenzothiazole compound, is a potent inhibitor of flavivirus RNA-dependent RNA polymerases (RdRp). It significantly inhibits the RdRp activity of West Nile, Dengue, and SARS-CoV-2 in vitro, with an IC50 of 27.6 µM.
HeE1-2Tyr
🥰Excellent
Purity: 95.86%
Catalog No. T9618Cas No. 2245195-67-7
HeE1-2Tyr, a pyridobenzothiazole compound, is a potent inhibitor of flavivirus RNA-dependent RNA polymerases (RdRp). It significantly inhibits the RdRp activity of West Nile, Dengue, and SARS-CoV-2 in vitro, with an IC50 of 27.6 µM.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | 62 € | In Stock | |
| 5 mg | 150 € | In Stock | |
| 10 mg | 249 € | In Stock | |
| 25 mg | 439 € | In Stock | |
| 50 mg | 620 € | In Stock | |
| 100 mg | 881 € | In Stock | |
| 1 mL x 10 mM (in DMSO) | 188 € | In Stock |
Bulk & Custom
Add to Cart
Questions
View MoreInhibitors Related to "HeE1-2Tyr"
Hydroxychloroquine
Cited
2-[[4-[(7-Chloroquinolin-4-yl)amino]pentyl](ethyl)amino]ethanol
T9287118-42-3
Hydroxychloroquine (2-[[4-[(7-Chloroquinolin-4-yl)amino]pentyl](ethyl)amino]ethanol) (HCQ) is an alkalinizing lysosomatropic drug that acts by inducing apoptosis of renal cancer cells in vitro and inhibiting TLR7/9. It is a medication used to prevent and treat malaria, and it's also being studied as an experimental treatment for COVID-19.
- 28 €
Size
QTY
CitedDexamethasone
Cited
Prednisolone F, NSC 34521, MK 125, Hexadecadrol
T107650-02-2
Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist and IL receptor modulator with anti-inflammatory and immunosuppressive properties that induces autophagy and inhibits LPS-induced inflammatory responses in macrophages.
ADC CytotoxinAntibacterialAntibioticAutophagyComplement SystemGlucocorticoid ReceptorIL ReceptorMitophagySARS-CoV
- 27 €
Size
QTY
CitedChloroquine phosphate Cited
Chloroquine diphosphate, Chingamin phosphate, Aralen phosphate
T019450-63-5
Chloroquine phosphate (Aralen phosphate) is an aminoquinoline antimalarial and also is widely used as an autophagy inhibitor. Chloroquine also is an inhibitor of toll-like receptors (TLRs).
- 39 €
Size
QTY
CitedSilymarin
Silybin B
T667065666-07-1
Silymarin (Silybin B) (Silybin B) is a polyphenolic flavonoid that extracts from the milk thistle or seeds of Silybum marianum. It is used in the prevention and treatment of liver diseases.
- 39 €
Size
QTY
Remdesivir Cited
GS-5734
T77661809249-37-3
Remdesivir (GS-5734) is a nucleoside analog, a broad-spectrum antiviral compound that exerts its activity by inhibiting the RNA-dependent RNA polymerase of viruses. Remdesivir is active against Ebola, SARS, and MERS viruses, and is potentially therapeutic against COVID-19.
- 115 €
Size
QTY
CitedEIDD-1931 Cited
Beta-d-N4-hydroxycytidine
T84983258-02-4
EIDD-1931 (Beta-d-N4-hydroxycytidine) is a ribonucleoside analog with antiviral activity that inhibits the replication of severe acute respiratory syndrome coronavirus [SARS-CoV] in Vero 76 cells, Middle East respiratory syndrome coronavirus [MERS-CoV] in Calu-3 2B4 cells, and SARS-CoV-2 in Vero cells (IC50s = 0.1, 0.15, and 0.3 μM, respectively).
- 31 €
Size
QTY
CitedUmifenovir hydrochloride Cited
Arbidol hydrochloride, Arbidol HCl
T0104131707-23-8
Umifenovir hydrochloride (Arbidol HCl) , an broad-spectrum antiviral chemical agent, can inhibit cell invade of enveloped viruses by blocking viral fusion with host cell membrane.
- 47 €
Size
QTY
CitedNirmatrelvir Cited
T93512628280-40-8
PF-07321332 is a potent and orally active inhibitor of SARS-CoV 3C-like protease (3CLPRO) .
- 50 €
Size
QTY
CitedFavipiravir Cited
T-705, 6-Fluoro-3-oxo-3,4-dihydropyrazine-2-carboxamide
T6833259793-96-9
Favipiravir is a potent and selective RNA-dependent RNA polymerase inhibitor for the treatment of influenza virus infections.
- 38 €
Size
QTY
CitedRitonavir Cited
RTV, ABT 538, Abbott 84538, A 84538
T1525155213-67-5
Ritonavir (ABT 538) is a peptidomimetic agent that inhibits both HIV-1 and HIV-2 proteases. Ritonavir is highly inhibited by serum proteins but boosts the effect of other HIV proteases by blocking their degradation by cytochrome P450.
- 29 €
Size
QTY
CitedAndrographolide Cited
Andrographis
T28985508-58-7
Andrographolide (Andrographis)(Andrographis), an irreversible antagonist of NF-κB, has anti-inflammatory and anti-platelet aggregation activities and potential antineoplastic.
- 45 €
Size
QTY
CitedBromhexine hydrochloride
Bromhexine HCl, Bisolvon, Auxit
T0828611-75-6
Bromhexine hydrochloride (Bisolvon) is a mucolytic agent used in the treatment of respiratory disorders associated with viscid or excessive mucus.
- 28 €
Size
QTY
Select Batch
Purity:95.86%
Contact us for more batch information
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | HeE1-2Tyr, a pyridobenzothiazole compound, is a potent inhibitor of flavivirus RNA-dependent RNA polymerases (RdRp). It significantly inhibits the RdRp activity of West Nile, Dengue, and SARS-CoV-2 in vitro, with an IC50 of 27.6 µM. |
| Targets&IC50 | RdRps (SARS CoV-2):27.6 µM |
| Molecular Weight | 582.67 |
| Formula | C33H30N2O6S |
| Cas No. | 2245195-67-7 |
| Smiles | OC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)c1cc(-c2ccccc2)c(=O)n2c3cc(OC4CCCCC4)ccc3sc12 |
| Relative Density. | 1.45 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 100 mg/mL (171.62 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
| ||||||||||||||||||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
Preview
Related Tags: buy HeE1-2Tyr | purchase HeE1-2Tyr | HeE1-2Tyr cost | order HeE1-2Tyr | HeE1-2Tyr chemical structure | HeE1-2Tyr formula | HeE1-2Tyr molecular weight
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.