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Hesperin

Catalog No. T15474Cas No. 4430-35-7
Alias 6-MSITC, 6MSITC, 6 MSITC

Hesperin (6-MSITC), a flavonoid isolated from orange peel, is a circadian decapping enzyme in plants, inhibiting lipid accumulation and production of reactive oxygen and nitrogen species in 3T3-L1 and RAW264.7 cells.

Hesperin

Hesperin

Purity: 98%
Catalog No. T15474Alias 6-MSITC, 6MSITC, 6 MSITCCas No. 4430-35-7
Hesperin (6-MSITC), a flavonoid isolated from orange peel, is a circadian decapping enzyme in plants, inhibiting lipid accumulation and production of reactive oxygen and nitrogen species in 3T3-L1 and RAW264.7 cells.
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1 mg(48.70 mM * 100 μL in Ethanol)$9835 days
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Concentration:10.0 mg/mL
Purity:98%
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Product Introduction

Bioactivity
Description
Hesperin (6-MSITC), a flavonoid isolated from orange peel, is a circadian decapping enzyme in plants, inhibiting lipid accumulation and production of reactive oxygen and nitrogen species in 3T3-L1 and RAW264.7 cells.
In vitro
b>METHODS: HUVEC cells were stimulated with TNF-a or thrombin in the presence of Hesperin (0.03, 0.1, 0.3, 1 µg/ml, 4 hours). The effect of Hesperin on VWF release induced by TNF-a and thrombin was studied.
RESULTS: Hesperin slightly increased TNF-a-induced TF activity, but at 1 lg/mL (4.88 μM), Hesperin reduced TNF-a- or thrombin-induced TF activity; Hesperin did not change the TF activity of unstimulated HUVECs; indicating that TF activity is inversely proportional to the concentration of Hesperin. [2]
In vivo
b>METHODS: Wild-type and Nrf2-deficient mice were fed the following diets for 12 weeks: 1) control diet, 2) high-fat diet (HFD), 3) HFD plus hesperin (10 mg/kg, ip, daily), 4) HFD for 6 weeks followed by HFD supplemented with iron for 6 weeks (HFD/iron), and 5) HFD/iron plus hesperin; to investigate whether hesperin could improve hepatic steatosis and iron accumulation.
RESULTS: HFD increased hepatic triglycerides in both genotypes and Hesperi; hesperin suppressed the increase in hepatic triglycerides in wild-type mice but did not reduce triglycerides in Nrf2-deficient mice; hesperin did not block hepatic iron accumulation in either genotype. [1]
Alias6-MSITC, 6MSITC, 6 MSITC
Chemical Properties
Molecular Weight205.34
FormulaC8H15NOS2
Cas No.4430-35-7
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 25 mg/mL (121.75 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM4.8700 mL24.3499 mL48.6997 mL243.4986 mL
5 mM0.9740 mL4.8700 mL9.7399 mL48.6997 mL
10 mM0.4870 mL2.4350 mL4.8700 mL24.3499 mL
20 mM0.2435 mL1.2175 mL2.4350 mL12.1749 mL
50 mM0.0974 mL0.4870 mL0.9740 mL4.8700 mL
100 mM0.0487 mL0.2435 mL0.4870 mL2.4350 mL

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