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iCRT 14

Catalog No. T4486Cas No. 677331-12-3

iCRT 14 is a novel and potent inhibitor of β-catenin-responsive transcription (CRT) with an IC50 of 40.3 nM in assays of Wnt pathway activity.

iCRT 14

iCRT 14

Purity: 99.8%
Catalog No. T4486Cas No. 677331-12-3
iCRT 14 is a novel and potent inhibitor of β-catenin-responsive transcription (CRT) with an IC50 of 40.3 nM in assays of Wnt pathway activity.
Pack SizePriceAvailabilityQuantity
2 mg$30In Stock
5 mg$48In Stock
10 mg$73In Stock
25 mg$123In Stock
50 mg$198In Stock
100 mg$372In Stock
1 mL x 10 mM (in DMSO)$53In Stock
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Purity:99.8%
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Product Introduction

Bioactivity
Description
iCRT 14 is a novel and potent inhibitor of β-catenin-responsive transcription (CRT) with an IC50 of 40.3 nM in assays of Wnt pathway activity.
Targets&IC50
Wnt responsive STF16 luciferase:40.3 nM
In vitro
iCRT14 can interfere with TCF binding to DNA in addition to its ability to influence TCF-β-cat interaction. iCRT14 (10, 25, 50 μM) effectively inhibits cell proliferation in BT-549 cells in a dose- and time-dependent manner but is still less potent than iCRT3.
In vivo
CRT14 (50 mg/kg, i.p.) markedly decreases CycD1, proliferation of the tumors in HCT116 xenografts.
Chemical Properties
Molecular Weight375.44
FormulaC21H17N3O2S
Cas No.677331-12-3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 12 mg/mL (31.96 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.6635 mL13.3177 mL26.6354 mL133.1771 mL
5 mM0.5327 mL2.6635 mL5.3271 mL26.6354 mL
10 mM0.2664 mL1.3318 mL2.6635 mL13.3177 mL
20 mM0.1332 mL0.6659 mL1.3318 mL6.6589 mL

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