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iCRT 14

Catalog No. T4486 CAS 677331-12-3

iCRT 14 is a novel potent inhibitor of β-catenin-responsive transcription (CRT)(IC50= 40.3 nM in assays of Wnt pathway activity).

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iCRT 14, CAS 677331-12-3

Pack Size	Availability	Price/USD
1 mg	In stock	$ 32.00
5 mg	In stock	$ 67.00
10 mg	In stock	$ 117.00
25 mg	In stock	$ 196.00
50 mg	In stock	$ 289.00
100 mg	In stock	$ 429.00
1 mL * 10 mM (in DMSO)	In stock	$ 74.00

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Purity: 99.8%

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Description	iCRT 14 is a novel potent inhibitor of β-catenin-responsive transcription (CRT)(IC50= 40.3 nM in assays of Wnt pathway activity).
Targets&IC50	Wnt responsive STF16 luciferase:40.3 nM
In vitro	iCRT14 can interfere with TCF binding to DNA in addition to its ability to influence TCF-β-cat interaction. iCRT14 (10, 25, 50 μM) effectively inhibits cell proliferation in BT-549 cells in a dose- and time-dependent manner but is still less potent than iCRT3.
In vivo	CRT14 (50 mg/kg, i.p.) markedly decreases CycD1, proliferation of the tumors in HCT116 xenografts.

Molecular Weight	375.44
Formula	C21H17N3O2S
CAS No.	677331-12-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 28 mg/mL (74.6 mM)

References and Literature

1. Gonsalves FC, et al. An RNAi-based chemical genetic screen identifies three small-molecule inhibitors of the Wnt/wingless signaling pathway. Proc Natl Acad Sci USA. 2011 Apr 12;108(15):5954-63. 2. Bilir B, et al. Wnt signaling blockage inhibits cell proliferation and migration, and induces apoptosis in triple-negative breast cancer cells. J Transl Med. 2013 Nov 4;11:280.

Citations

1. Wang C, Wang T, Hu R, et al.9-Butyl-Harmol Exerts Antiviral Activity against Newcastle Disease Virus through Targeting GSK-3β and HSP90β.Journal of Virology.2023: e01984-22. 2. Wang T, Wang C, Han J, et al.β-catenin facilitates fowl adenovirus serotype 4 replication through enhancing virus-induced autophagy.Veterinary Microbiology.2022: 109617.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Stem Cell Differentiation Compound Library Anti-Lung Cancer Compound Library Anti-Aging Compound Library Bioactive Compounds Library Max Anti-Prostate Cancer Compound Library NO PAINS Compound Library Anti-Ovarian Cancer Compound Library Neural Regeneration Compound Library Anti-Cancer Metabolism Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

iCRT 14 677331-12-3 Cytoskeletal Signaling Stem Cells Wnt/beta-catenin iCRT14 iCRT-14 Wnt Inhibitor inhibit inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.