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iCRT 14 is a novel and potent inhibitor of β-catenin-responsive transcription (CRT) with an IC50 of 40.3 nM in assays of Wnt pathway activity.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
2 mg | $30 | In Stock | |
5 mg | $48 | In Stock | |
10 mg | $73 | In Stock | |
25 mg | $123 | In Stock | |
50 mg | $198 | In Stock | |
100 mg | $372 | In Stock | |
1 mL x 10 mM (in DMSO) | $53 | In Stock |
Description | iCRT 14 is a novel and potent inhibitor of β-catenin-responsive transcription (CRT) with an IC50 of 40.3 nM in assays of Wnt pathway activity. |
Targets&IC50 | Wnt responsive STF16 luciferase:40.3 nM |
In vitro | iCRT14 can interfere with TCF binding to DNA in addition to its ability to influence TCF-β-cat interaction. iCRT14 (10, 25, 50 μM) effectively inhibits cell proliferation in BT-549 cells in a dose- and time-dependent manner but is still less potent than iCRT3. |
In vivo | CRT14 (50 mg/kg, i.p.) markedly decreases CycD1, proliferation of the tumors in HCT116 xenografts. |
Molecular Weight | 375.44 |
Formula | C21H17N3O2S |
Cas No. | 677331-12-3 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
Solubility Information | DMSO: 12 mg/mL (31.96 mM), Sonication is recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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