Powder: -20°C for 3 years | In solvent: -80°C for 1 year
iMDK quarterhydrate is a potent PI3K inhibitor that inhibits the growth factor MDK (also known as midkine or MK). iMDK quarterhydrate synergistically inhibits non-small cell lung cancer (NSCLC) with MEK inhibitors without harming normal cells and mice.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 54.00 | |
5 mg | In stock | $ 128.00 | |
10 mg | In stock | $ 197.00 | |
25 mg | In stock | $ 455.00 | |
50 mg | In stock | $ 672.00 | |
100 mg | In stock | $ 956.00 | |
500 mg | In stock | $ 1,920.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 186.00 |
Description | iMDK quarterhydrate is a potent PI3K inhibitor that inhibits the growth factor MDK (also known as midkine or MK). iMDK quarterhydrate synergistically inhibits non-small cell lung cancer (NSCLC) with MEK inhibitors without harming normal cells and mice. |
In vitro | Administration of iMDK (50-500 nM) for 72 h quarterhydrate suppressed AKT phosphorylation in H441 lung adenocarcinoma cells after treatment dose-dependently. In contrast, iMDK quarterhydrate robustly increases p-ERK[1]. |
In vivo | Intraperitoneally injection with 100 μl of iMDK ( (9 mg/kg/day) and ; oral administion of PD0325901 (5 mg/kg) effectively reduced lung tumor growth in a xenograft mouse model[1]. |
Molecular Weight | 376.4 |
Formula | C21H13FN2O2S |
CAS No. | 881970-80-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 3.76 mg/mL (10 mM), Sonification is recommended
You can also refer to dose conversion for different animals. More
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iMDK 881970-80-5 PI3K/Akt/mTOR signaling PI3K inhibit midkine factor NSCLC growth Inhibitor Phosphoinositide 3-kinase MDK inhibitor