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iMDK

iMDK
iMDK quarterhydrate is a potent PI3K inhibitor that inhibits the growth factor MDK (also known as midkine or MK). iMDK quarterhydrate synergistically inhibits non-small cell lung cancer (NSCLC) with MEK inhibitors without harming normal cells and mice.
Catalog No. T9460Cas No. 881970-80-5
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Purity:99.77%
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iMDK

Purity: 99.77%
Catalog No. T9460Cas No. 881970-80-5

iMDK quarterhydrate is a potent PI3K inhibitor that inhibits the growth factor MDK (also known as midkine or MK). iMDK quarterhydrate synergistically inhibits non-small cell lung cancer (NSCLC) with MEK inhibitors without harming normal cells and mice.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
1 mg$54In Stock
5 mg$128In Stock
10 mg$197In Stock
25 mg$455In Stock
50 mg$672In Stock
100 mg$956In Stock
500 mg$1,920In Stock
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Product Introduction

Bioactivity
Description
iMDK quarterhydrate is a potent PI3K inhibitor that inhibits the growth factor MDK (also known as midkine or MK). iMDK quarterhydrate synergistically inhibits non-small cell lung cancer (NSCLC) with MEK inhibitors without harming normal cells and mice.
In vitro
Administration of iMDK (50-500 nM) for 72 h quarterhydrate suppressed AKT phosphorylation in H441 lung adenocarcinoma cells after treatment dose-dependently. In contrast, iMDK quarterhydrate robustly increases p-ERK[1].
In vivo
Intraperitoneally injection with 100 μl of iMDK ( (9 mg/kg/day) and ; oral administion of PD0325901 (5 mg/kg) effectively reduced lung tumor growth in a xenograft mouse model[1].
Chemical Properties
Molecular Weight376.4
FormulaC21H13FN2O2S
Cas No.881970-80-5
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 3.76 mg/mL (10 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.6567 mL13.2837 mL26.5675 mL132.8374 mL
5 mM0.5313 mL2.6567 mL5.3135 mL26.5675 mL
10 mM0.2657 mL1.3284 mL2.6567 mL13.2837 mL

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