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Product Introduction

Bioactivity

Description	Ibotenic acid (RS-42358-197) has agonist activity at both the NMDA and trans-ACPD or metabotropic quisqualate receptors.
In vitro	Ibotenic acid is toxic to cortical neurons exposes for 5 min with an EC50=77.3 μM as measured by the release of lactate dehydrogenase to the culture media[1].
Alias	Ibotenate, DL-Ibotenic acid, (RS)-Ibotenic acid, (+/-)-Ibotenic acid

Chemical Properties

Molecular Weight	158.11
Formula	C₅H₆N₂O₄
Cas No.	2552-55-8

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 5 mg/mL (31.62 mM), Sonication is recommended.

H2O: 5 mg/mL (31.62 mM), Sonication and heating are recommended.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	6.3247 mL	31.6236 mL	63.2471 mL	316.2355 mL
5 mM	1.2649 mL	6.3247 mL	12.6494 mL	63.2471 mL
10 mM	0.6325 mL	3.1624 mL	6.3247 mL	31.6236 mL
20 mM	0.3162 mL	1.5812 mL	3.1624 mL	15.8118 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Ibotenic acid