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IDF-11774

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Catalog No. T5537Cas No. 1429054-28-3

IDF-11774 is a HIF-1 inhibitor.It reduces hif-1α HRE luciferase activity (IC50 = 3.65 μM).

IDF-11774

IDF-11774

🥰Excellent
Purity: 98.05%
Catalog No. T5537Cas No. 1429054-28-3
IDF-11774 is a HIF-1 inhibitor.It reduces hif-1α HRE luciferase activity (IC50 = 3.65 μM).
Pack SizePriceAvailabilityQuantity
1 mg$55In Stock
5 mg$113In Stock
10 mg$197In Stock
25 mg$328In Stock
50 mg$489In Stock
100 mg$713In Stock
1 mL x 10 mM (in DMSO)$92In Stock
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Purity:98.05%
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Product Introduction

Bioactivity
Description
IDF-11774 is a HIF-1 inhibitor.It reduces hif-1α HRE luciferase activity (IC50 = 3.65 μM).
Targets&IC50
HIF1α:3.65 μM
In vitro
IDF-11774 treatment suppressed angiogenesis of cancer cells by reducing the expression of HIF-1 target genes, reduced glucose uptake, thereby sensitizing cells to growth under low glucose conditions, and decreased the extracellular acidification rate (ECAR) and oxygen consumption rate of cancer cells.
In vivo
Luciferase activity and HIF-1α accumulation are significantly suppressed in the tumors of mice treated with oral administration of IDF-11774, compared to the control.
Animal Research
When IDF-11774 is orally administered daily for two weeks, significant dose-dependent tumor regression is observed in the mouse model.
Chemical Properties
Molecular Weight368.51
FormulaC23H32N2O2
Cas No.1429054-28-3
SmilesCN1CCN(CC1)C(=O)COc1ccc(cc1)C12CC3CC(CC(C3)C1)C2
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 60 mg/mL (162.82 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.7136 mL13.5682 mL27.1363 mL135.6815 mL
5 mM0.5427 mL2.7136 mL5.4273 mL27.1363 mL
10 mM0.2714 mL1.3568 mL2.7136 mL13.5682 mL
20 mM0.1357 mL0.6784 mL1.3568 mL6.7841 mL
50 mM0.0543 mL0.2714 mL0.5427 mL2.7136 mL
100 mM0.0271 mL0.1357 mL0.2714 mL1.3568 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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