Powder: -20°C for 3 years | In solvent: -80°C for 1 year
inS3-54A18 is an effective inhibitor of STAT3. inS3-54A18 has anticancer effects.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 68.00 | |
2 mg | In stock | $ 97.00 | |
5 mg | In stock | $ 157.00 | |
10 mg | In stock | $ 257.00 | |
25 mg | In stock | $ 533.00 | |
50 mg | In stock | $ 773.00 | |
100 mg | In stock | $ 1,080.00 | |
500 mg | In stock | $ 2,170.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 129.00 |
Description | inS3-54A18 is an effective inhibitor of STAT3. inS3-54A18 has anticancer effects. |
In vitro | inS3-54A18 selectively impedes STAT3's interaction with its inherent target sequences and diminishes the expression of genes downstream of STAT3. It significantly reduces the wound healing capacity in A549 and MDA-MB-231 cells to 64% and 76% at a concentration of 5μM, and further decreases healing to 47% and 39%, respectively, at 10μM. Notably, inS3-54A18 does not interfere with either the basal or IL-6-stimulated activation of STAT3, but specifically inhibits the expression of a STAT3 target gene, survivin. |
In vivo | inS3-54A18 (200 mg/kg, p.o.) inhibits tumor growth, metastasis. In a mouse xenograft model of A549 cells, inS3-54A18 (200 mg/kg, p.o.) also inhibits expression of STAT3 target genes[1]. |
Molecular Weight | 373.83 |
Formula | C23H16ClNO2 |
CAS No. | 328998-53-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 150 mg/mL (401.25 mM)
You can also refer to dose conversion for different animals. More
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inS3-54A18 328998-53-4 JAK/STAT signaling Stem Cells STAT Inhibitor inS-3-54A18 inS3 54A18 inS354A18 inhibit inhibitor