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inS3-54A18
Catalog No. T15582Cas No. 328998-53-4
inS3-54A18 is an effective inhibitor of STAT3. inS3-54A18 has anticancer effects.
inS3-54A18
Catalog No. T15582Cas No. 328998-53-4
inS3-54A18 is an effective inhibitor of STAT3. inS3-54A18 has anticancer effects.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $35 | In Stock | |
| 5 mg | $59 | In Stock | |
| 10 mg | $94 | In Stock | |
| 25 mg | $163 | In Stock | |
| 50 mg | $238 | In Stock | |
| 100 mg | $337 | In Stock | |
| 200 mg | $475 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $65 | In Stock |
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Purity:99.54%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | inS3-54A18 is an effective inhibitor of STAT3. inS3-54A18 has anticancer effects. |
| In vitro | inS3-54A18 selectively impedes STAT3's interaction with its inherent target sequences and diminishes the expression of genes downstream of STAT3. It significantly reduces the wound healing capacity in A549 and MDA-MB-231 cells to 64% and 76% at a concentration of 5μM, and further decreases healing to 47% and 39%, respectively, at 10μM. Notably, inS3-54A18 does not interfere with either the basal or IL-6-stimulated activation of STAT3, but specifically inhibits the expression of a STAT3 target gene, survivin. |
| In vivo | inS3-54A18 (200 mg/kg, p.o.) inhibits tumor growth, metastasis, and STAT3 target gene expression in an A549 cell mouse xenograft model[1]. |
| Molecular Weight | 373.83 |
| Formula | C23H16ClNO2 |
| Cas No. | 328998-53-4 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 150 mg/mL (401.25 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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