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inS3-54A18

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Purity:99.54%

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COA HNMR LCMS

inS3-54A18

Catalog No. T15582Cas No. 328998-53-4

inS3-54A18 is an effective inhibitor of STAT3. inS3-54A18 has anticancer effects.

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Pack Size	Price	Availability
1 mg	$42	In Stock
2 mg	$59	In Stock
5 mg	$98	In Stock
10 mg	$156	In Stock
25 mg	$272	In Stock
50 mg	$396	In Stock
100 mg	$562	In Stock
500 mg	$1,190	In Stock
1 mL x 10 mM (in DMSO)	$108	In Stock

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Product Introduction

Bioactivity

Description	inS3-54A18 is an effective inhibitor of STAT3. inS3-54A18 has anticancer effects.
In vitro	inS3-54A18 selectively impedes STAT3's interaction with its inherent target sequences and diminishes the expression of genes downstream of STAT3. It significantly reduces the wound healing capacity in A549 and MDA-MB-231 cells to 64% and 76% at a concentration of 5μM, and further decreases healing to 47% and 39%, respectively, at 10μM. Notably, inS3-54A18 does not interfere with either the basal or IL-6-stimulated activation of STAT3, but specifically inhibits the expression of a STAT3 target gene, survivin.
In vivo	inS3-54A18 (200 mg/kg, p.o.) inhibits tumor growth, metastasis. In a mouse xenograft model of A549 cells, inS3-54A18 (200 mg/kg, p.o.) also inhibits expression of STAT3 target genes[1].

Chemical Properties

Molecular Weight	373.83
Formula	C23H16ClNO2
Cas No.	328998-53-4

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 150 mg/mL (401.25 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6750 mL	13.3751 mL	26.7501 mL	133.7506 mL
5 mM	0.5350 mL	2.6750 mL	5.3500 mL	26.7501 mL
10 mM	0.2675 mL	1.3375 mL	2.6750 mL	13.3751 mL
20 mM	0.1338 mL	0.6688 mL	1.3375 mL	6.6875 mL
50 mM	0.0535 mL	0.2675 mL	0.5350 mL	2.6750 mL
100 mM	0.0268 mL	0.1338 mL	0.2675 mL	1.3375 mL

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In Vivo Formulation Calculator (Clear solution)

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

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mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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