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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $113 | In Stock | |
5 mg | $247 | In Stock | |
10 mg | $413 | In Stock | |
25 mg | $672 | In Stock | |
50 mg | $936 | In Stock | |
100 mg | $1,260 | In Stock | |
1 mL x 10 mM (in DMSO) | $272 | In Stock |
Description | JNJ-61432059 is an oral active and selective negative modulator of AMPAR associated with trans-membrane AMPAR regulatory protein (TARP) γ-8 (pIC50: 9.7 for GluA1/γ-8). |
In vivo | In mouse hippocampus, Exhibits time- and dose-dependent AMPAR/γ-8 receptor occupancy, resulting in robust seizure protection in corneal kindling and pentylenetetrazole (PTZ) anticonvulsant models. |
Molecular Weight | 443.47 |
Formula | C25H22FN5O2 |
Cas No. | 2035814-50-5 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 65 mg/mL (146.57 mM) ![]() | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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