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JNJ-61432059
🥰Excellent
Catalog No. T15623Cas No. 2035814-50-5
JNJ-61432059 is an orally active and selective negative modulator of TARP γ-8 selective AMPAR (pIC50: 9.7).
JNJ-61432059
🥰Excellent
Purity: 98.13%
Catalog No. T15623Cas No. 2035814-50-5
JNJ-61432059 is an orally active and selective negative modulator of TARP γ-8 selective AMPAR (pIC50: 9.7).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $113 | In Stock | |
| 5 mg | $247 | In Stock | |
| 10 mg | $413 | In Stock | |
| 25 mg | $672 | In Stock | |
| 50 mg | $936 | In Stock | |
| 100 mg | $1,260 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $272 | In Stock |
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Purity:98.13%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | JNJ-61432059 is an orally active and selective negative modulator of TARP γ-8 selective AMPAR (pIC50: 9.7). |
| Targets&IC50 | AMPAR:(pic50)9.7 |
| In vivo | In mouse hippocampus, Exhibits time- and dose-dependent AMPAR/γ-8 receptor occupancy, resulting in robust seizure protection in corneal kindling and pentylenetetrazole (PTZ) anticonvulsant models. |
| Molecular Weight | 443.47 |
| Formula | C25H22FN5O2 |
| Cas No. | 2035814-50-5 |
| Smiles | OC1CCN(CC1)c1nccc2c(c(nn12)-c1ccc(F)cc1)-c1ccc2NC(=O)Cc2c1 |
| Relative Density. | 1.49 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 65 mg/mL (146.57 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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