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JNJ-7777120

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Catalog No. T2232Cas No. 459168-41-3
Alias JNJ7777120

JNJ-7777120 is the first potent and selective non-imidazole histamine H4 receptor antagonist with Ki of 4.5 nM, exhibits >1000-fold selectivity over the other histamin receptors.

JNJ-7777120

JNJ-7777120

🥰Excellent
Purity: 99.93%
Catalog No. T2232Alias JNJ7777120Cas No. 459168-41-3
JNJ-7777120 is the first potent and selective non-imidazole histamine H4 receptor antagonist with Ki of 4.5 nM, exhibits >1000-fold selectivity over the other histamin receptors.
Pack SizePriceAvailabilityQuantity
5 mg$64In Stock
10 mg$97In Stock
25 mg$173In Stock
50 mg$288In Stock
100 mg$463In Stock
500 mg$987In Stock
1 mL x 10 mM (in DMSO)$67In Stock
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Purity:99.93%
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Product Introduction

Bioactivity
Description
JNJ-7777120 is the first potent and selective non-imidazole histamine H4 receptor antagonist with Ki of 4.5 nM, exhibits >1000-fold selectivity over the other histamin receptors.
Targets&IC50
H4 receptor:4.5 nM(Ki)
In vitro
JNJ 7777120 administration in mice inhibits the migration of tracheal mast cells from connective to epithelial tissues induced by histamine. Furthermore, JNJ 7777120 treatment in mice-derived bone marrow mast cells suppresses histamine-induced chemotaxis and calcium influx. In a peritonitis model induced by yeast polysaccharides in mice, JNJ 7777120 markedly inhibits neutrophil infiltration. The compound demonstrates oral bioavailability, with a 30% rate in rats and 100% in dogs, and a half-life of 3 hours for both species.
In vivo
JNJ 7777120 is an effective, selective antagonist for the H4 receptor, with little to no affinity for over 50 other targets. It binds with high affinity to the H4 receptor, exhibiting over a thousand times greater selectivity compared to other histamine receptors.
AliasJNJ7777120
Chemical Properties
Molecular Weight277.75
FormulaC14H16ClN3O
Cas No.459168-41-3
SmilesC(=O)(C1=CC=2C(N1)=CC=C(Cl)C2)N3CCN(C)CC3
Relative Density.1.322g/cm3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
1eq. HCl: 27.8 mg/mL (100 mM)
DMSO: 40 mg/mL (144.01 mM)
Solution Preparation Table
1eq. HCl/DMSO
1mg5mg10mg50mg
1 mM3.6004 mL18.0018 mL36.0036 mL180.0180 mL
5 mM0.7201 mL3.6004 mL7.2007 mL36.0036 mL
10 mM0.3600 mL1.8002 mL3.6004 mL18.0018 mL
20 mM0.1800 mL0.9001 mL1.8002 mL9.0009 mL
50 mM0.0720 mL0.3600 mL0.7201 mL3.6004 mL
100 mM0.0360 mL0.1800 mL0.3600 mL1.8002 mL

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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