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JW74
🥰Excellent
Catalog No. T15633Cas No. 863405-60-1
JW74 antagonizes LiCl-induced activation of the canonical Wnt signaling pathway (IC50: 420 nM).
JW74
🥰Excellent
Purity: 95.00%
Catalog No. T15633Cas No. 863405-60-1
JW74 antagonizes LiCl-induced activation of the canonical Wnt signaling pathway (IC50: 420 nM).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $34 | In Stock | |
| 10 mg | $44 | In Stock | |
| 25 mg | $98 | In Stock | |
| 50 mg | $148 | In Stock | |
| 100 mg | $208 | In Stock | |
| 200 mg | $297 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $37 | In Stock |
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Purity:95.00%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | JW74 antagonizes LiCl-induced activation of the canonical Wnt signaling pathway (IC50: 420 nM). |
| Targets&IC50 | Wnt:420 nM |
| In vitro | Ki-67 expression is reduced from 97.5% in DMSO-treated cells to 86.7% in JW74-treated cells. Relative to DMSO-treated cells, the cellular viability of U2OS cells treated for 72 h treatment with 10 μM JW74 is reduced to 80%. The effect of tankyrase inhibition on cellular viability is tested by performing an MTS assay. Flow cytometry is also performed to determine the expression marker Ki-67 in U2OS following 48 h treatment with DMSO or 10 uM JW74 [2]. JW74 displays a reduction of canonical Wnt signaling in the ST-Luc assay (IC50: 790 nM) [1]. |
| In vivo | The in vivo efficacy of JW74 is evaluated using SW480 cell xenografts, with high doses (150 or 300 mg/kg) administered due to rapid degradation in the organism, as shown by human liver microsome analysis (t1/2=2.5 minutes) and pharmacokinetic analyses (t1/2=30 minutes after peroral injections and t1/2=15 minutes after intravenous injections). JW74 concentrations in tumors range from 4.2 to 72.1 μmol/kg for 150 mg/kg, 1.9 to 11.1 μmol/kg for 300 mg/kg, and reach 2.8 μM in plasma for both doses [1]. |
| Molecular Weight | 456.52 |
| Formula | C24H20N6O2S |
| Cas No. | 863405-60-1 |
| Smiles | COc1ccc(cc1)-n1c(SCc2nc(no2)-c2ccc(C)cc2)nnc1-c1ccncc1 |
| Relative Density. | 1.35 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 45 mg/mL (98.57 mM) | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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