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KL1333
🥰Excellent
Catalog No. T16342Cas No. 1800405-30-4
Alias NQO1 activator 1
KL1333 (NQO1 activator 1) enhances energy metabolism and mitochondrial dysfunction in MELAS fibroblasts. Elevated NAD+ levels trigger the activation of SIRT1 and AMPK, and subsequently activates PGC-1α. NQO1 activator 1 is an orally available NAD+ modulator. It reacts with NAD(P)H: NQO1 as a substrate, resulting in increases in intracellular NAD+ levels via NADH oxidation.
KL1333
🥰Excellent
Purity: 99.27%
Catalog No. T16342Alias NQO1 activator 1Cas No. 1800405-30-4
KL1333 (NQO1 activator 1) enhances energy metabolism and mitochondrial dysfunction in MELAS fibroblasts. Elevated NAD+ levels trigger the activation of SIRT1 and AMPK, and subsequently activates PGC-1α. NQO1 activator 1 is an orally available NAD+ modulator. It reacts with NAD(P)H: NQO1 as a substrate, resulting in increases in intracellular NAD+ levels via NADH oxidation.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $95 | In Stock | |
| 5 mg | $192 | In Stock | |
| 10 mg | $289 | In Stock | |
| 25 mg | $523 | In Stock | |
| 50 mg | $787 | In Stock | |
| 100 mg | $1,070 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $253 | In Stock |
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CitedSelect Batch
Purity:99.27%
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Product Introduction
Bioactivity
Chemical Properties
| Description | KL1333 (NQO1 activator 1) enhances energy metabolism and mitochondrial dysfunction in MELAS fibroblasts. Elevated NAD+ levels trigger the activation of SIRT1 and AMPK, and subsequently activates PGC-1α. NQO1 activator 1 is an orally available NAD+ modulator. It reacts with NAD(P)H: NQO1 as a substrate, resulting in increases in intracellular NAD+ levels via NADH oxidation. |
| Alias | NQO1 activator 1 |
| Molecular Weight | 240.26 |
| Formula | C14H12N2O2 |
| Cas No. | 1800405-30-4 |
| Smiles | CC(C)c1nc-2c([nH]1)C(=O)C(=O)c1ccccc-21 |
| Relative Density. | 1.329 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 245 mg/mL (1019.73 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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