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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $35 | In Stock | |
5 mg | $89 | In Stock | |
10 mg | $147 | In Stock | |
25 mg | $288 | In Stock | |
50 mg | $479 | In Stock | |
100 mg | $768 | In Stock | |
1 mL x 10 mM (in DMSO) | $98 | In Stock |
Description | LC3-mHTT-IN-AN1 is a mHTT-LC3 linker compound that interacts with both mutant huntingtin protein (mHTT) and LC3B. LC3-mHTT-IN-AN1 targeted mHTT to autophagosomes reduces the levels of mHTT in an allele-selective manner in cultured Huntington disease (HD) mouse neurons. |
In vitro | LC3-mHTT-IN-AN1 targeted mHTT to autophagosomes, reduced mHTT levels in an allele-selective manner, and rescued disease-relevant phenotypes in cells and in vivo in fly and mouse models of Huntington's disease. |
Molecular Weight | 411.04 |
Formula | C15H9Br2NO3 |
Cas No. | 486443-73-6 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 120 mg/mL (291.94 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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