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LC3-mHTT-IN-AN1

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Purity:97.26%

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COA HNMR LCMS

LC3-mHTT-IN-AN1

Catalog No. T8081Cas No. 486443-73-6

LC3-mHTT-IN-AN1 is a mHTT-LC3 linker compound that interacts with both mutant huntingtin protein (mHTT) and LC3B. LC3-mHTT-IN-AN1 targeted mHTT to autophagosomes reduces the levels of mHTT in an allele-selective manner in cultured Huntington disease (HD) mouse neurons.

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Pack Size	Price	Availability
1 mg	$35	In Stock
5 mg	$89	In Stock
10 mg	$147	In Stock
25 mg	$288	In Stock
50 mg	$479	In Stock
100 mg	$768	In Stock
1 mL x 10 mM (in DMSO)	$98	In Stock

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Product Introduction

Bioactivity

Description	LC3-mHTT-IN-AN1 is a mHTT-LC3 linker compound that interacts with both mutant huntingtin protein (mHTT) and LC3B. LC3-mHTT-IN-AN1 targeted mHTT to autophagosomes reduces the levels of mHTT in an allele-selective manner in cultured Huntington disease (HD) mouse neurons.
In vitro	LC3-mHTT-IN-AN1 targeted mHTT to autophagosomes, reduced mHTT levels in an allele-selective manner, and rescued disease-relevant phenotypes in cells and in vivo in fly and mouse models of Huntington's disease.

Chemical Properties

Molecular Weight	411.04
Formula	C15H9Br2NO3
Cas No.	486443-73-6

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 120 mg/mL (291.94 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4329 mL	12.1643 mL	24.3285 mL	121.6427 mL
5 mM	0.4866 mL	2.4329 mL	4.8657 mL	24.3285 mL
10 mM	0.2433 mL	1.2164 mL	2.4329 mL	12.1643 mL
20 mM	0.1216 mL	0.6082 mL	1.2164 mL	6.0821 mL
50 mM	0.0487 mL	0.2433 mL	0.4866 mL	2.4329 mL
100 mM	0.0243 mL	0.1216 mL	0.2433 mL	1.2164 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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