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LDH-IN-1

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Catalog No. T11829Cas No. 1964515-43-2

LDH-IN-1 is a pyrazole-based human lactate dehydrogenase (LDH) inhibitor(IC50s of 32 and 27 nM for LDHA and LDHB, respectively).

LDH-IN-1

LDH-IN-1

🥰Excellent
Purity: 99.60%
Catalog No. T11829Cas No. 1964515-43-2
LDH-IN-1 is a pyrazole-based human lactate dehydrogenase (LDH) inhibitor(IC50s of 32 and 27 nM for LDHA and LDHB, respectively).
Pack SizePriceAvailabilityQuantity
1 mg$213In Stock
2 mg$297In Stock
5 mg$455In Stock
10 mg$672In Stock
25 mg$1,060In Stock
50 mg$1,430In Stock
100 mg$1,920In Stock
1 mL x 10 mM (in DMSO)$573In Stock
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Purity:99.60%
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Product Introduction

Bioactivity
Description
LDH-IN-1 is a pyrazole-based human lactate dehydrogenase (LDH) inhibitor(IC50s of 32 and 27 nM for LDHA and LDHB, respectively).
Targets&IC50
LDHB:27 nM (IC50), LDHA:32 nM (IC50)
In vitro
LDH-IN-1 exhibit low nM inhibition of both LDHA and LDHB, submicromolar inhibition of lactate production, and inhibition of glycolysis in MiaPaCa2 pancreatic cancer and A673 sarcoma cells.
In vivo
LDH-IN-1 exhibits clearance rates significantly surpassing those of hepatic blood flow in mice (90 mL/min/kg), demonstrating an in vivo clearance of 227 mL/min/kg[1].
Chemical Properties
Molecular Weight570.68
FormulaC30H26N4O4S2
Cas No.1964515-43-2
SmilesNS(=O)(=O)c1ccc(Cc2c(CC3CC3)n(nc2-c2cccc(c2)-c2ccccc2)-c2nc(cs2)C(O)=O)cc1
Relative Density.1.46 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 50 mg/mL (87.61 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.7523 mL8.7615 mL17.5230 mL87.6148 mL
5 mM0.3505 mL1.7523 mL3.5046 mL17.5230 mL
10 mM0.1752 mL0.8761 mL1.7523 mL8.7615 mL
20 mM0.0876 mL0.4381 mL0.8761 mL4.3807 mL
50 mM0.0350 mL0.1752 mL0.3505 mL1.7523 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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