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LDH-IN-1

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Purity:99.84%

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COA HPLC HNMR

LDH-IN-1

Catalog No. T11829Cas No. 1964515-43-2

LDH-IN-1 is a pyrazole-based human lactate dehydrogenase (LDH) inhibitor(IC50s of 32 and 27 nM for LDHA and LDHB, respectively).

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Pack Size	Price	Availability
1 mg	$213	In Stock
2 mg	$297	In Stock
5 mg	$455	In Stock
10 mg	$672	In Stock
25 mg	$1,060	In Stock
50 mg	$1,430	In Stock
100 mg	$1,920	In Stock
1 mL x 10 mM (in DMSO)	$573	In Stock

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Product Introduction

Bioactivity

Description	LDH-IN-1 is a pyrazole-based human lactate dehydrogenase (LDH) inhibitor(IC50s of 32 and 27 nM for LDHA and LDHB, respectively).
In vitro	LDH-IN-1 exhibit low nM inhibition of both LDHA and LDHB, submicromolar inhibition of lactate production, and inhibition of glycolysis in MiaPaCa2 pancreatic cancer and A673 sarcoma cells.
In vivo	LDH-IN-1 exhibits clearance rates significantly surpassing those of hepatic blood flow in mice (90 mL/min/kg), demonstrating an in vivo clearance of 227 mL/min/kg[1].

Chemical Properties

Molecular Weight	570.68
Formula	C30H26N4O4S2
Cas No.	1964515-43-2

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (87.61 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7523 mL	8.7615 mL	17.5230 mL	87.6148 mL
5 mM	0.3505 mL	1.7523 mL	3.5046 mL	17.5230 mL
10 mM	0.1752 mL	0.8761 mL	1.7523 mL	8.7615 mL
20 mM	0.0876 mL	0.4381 mL	0.8761 mL	4.3807 mL
50 mM	0.0350 mL	0.1752 mL	0.3505 mL	1.7523 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc