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LDHA-IN-3
🥰Excellent
Catalog No. T39805Cas No. 227010-33-5
Alias PSTMB, 1-(phenylseleno)-4-(trifluoromethyl) benzene
LDHA-IN-3 (1-(phenylseleno)-4-(trifluoromethyl) benzene) is a potent non-competitive lactate dehydrogenase (LDHA) inhibitor with an IC50 value of 145.2 nM.LDHA-IN-3 is a selenobenzene compound that can be used in cancer research.
LDHA-IN-3
🥰Excellent
Purity: 99.77%
Catalog No. T39805Alias PSTMB, 1-(phenylseleno)-4-(trifluoromethyl) benzeneCas No. 227010-33-5
LDHA-IN-3 (1-(phenylseleno)-4-(trifluoromethyl) benzene) is a potent non-competitive lactate dehydrogenase (LDHA) inhibitor with an IC50 value of 145.2 nM.LDHA-IN-3 is a selenobenzene compound that can be used in cancer research.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $50 | In Stock | |
| 5 mg | $122 | In Stock | |
| 10 mg | $196 | In Stock | |
| 25 mg | $413 | In Stock | |
| 50 mg | $615 | In Stock | |
| 100 mg | $876 | In Stock | |
| 500 mg | $1,780 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $133 | In Stock |
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CitedSelect Batch
Purity:99.77%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | LDHA-IN-3 (1-(phenylseleno)-4-(trifluoromethyl) benzene) is a potent non-competitive lactate dehydrogenase (LDHA) inhibitor with an IC50 value of 145.2 nM.LDHA-IN-3 is a selenobenzene compound that can be used in cancer research. |
| Targets&IC50 | LDHA:145.2 nM (IC50) |
| In vitro | LDHA-IN-3 (PSTMB) (0~500 μM; 48 h; MCF-7 cells) has cytotoxic effects.[1] PSTMB (0.01~1 μM) has a dose-dependent inhibitory effect on LDHA activity. PSTMB (0~0.5 μM) inhibits LDHA activity in Michaelis-Menten and Lineweaver-Burk plots.[1] PSTMB (30 and 50 μM; HT29 cells) induces ROS production and mitochondrial damage.[1] PSTMB efficiently binds to LDHA protein. PSTMB induces intrinsic pathway-mediated apoptosis in cancer cells through the production of mitochondrial ROS.[1] |
| Alias | PSTMB, 1-(phenylseleno)-4-(trifluoromethyl) benzene |
| Molecular Weight | 301.17 |
| Formula | C13H9F3Se |
| Cas No. | 227010-33-5 |
| Smiles | [Se](C1=CC=C(C(F)(F)F)C=C1)C2=CC=CC=C2 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 60 mg/mL (199.22 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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