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MA-0204

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Purity:98.83%

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COA HPLC HNMR

MA-0204

Catalog No. T15945Cas No. 2095128-17-7

MA-0204 is a highly selective and orally available peroxisome proliferator-activated receptor δ (PPARδ) modulator (EC50s: 0.4 nM, 7.9 nM and 10 nM for human, mouse and rat PPARδ, respectively). It is a potential treatment for Duchene Muscular Dystrophy (DMD).

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Pack Size	Price	Availability
1 mg	$147	In Stock
5 mg	$313	In Stock
10 mg	$528	In Stock
25 mg	$859	In Stock
50 mg	$1,190	In Stock
100 mg	$1,580	In Stock
1 mL x 10 mM (in DMSO)	$329	In Stock

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Product Introduction

Bioactivity

Description	MA-0204 is a highly selective and orally available peroxisome proliferator-activated receptor δ (PPARδ) modulator (EC50s: 0.4 nM, 7.9 nM and 10 nM for human, mouse and rat PPARδ, respectively). It is a potential treatment for Duchene Muscular Dystrophy (DMD).
Targets&IC50	PPARδ:7.9 nM (EC50)(in mouse), PPARδ:10 nM (EC50)(in rat), PPARδ:0.4 nM (EC50)(in human)
In vitro	MA-0204 is >10,000-fold selective for activating PPARδ over PPARα and PPARγ receptors. At concentrations of 1.2-12 nM, MA-0204 enhances fatty acid oxidation in muscle myoblasts from DMD patients in mice, shows high protein binding in mouse plasma, exhibits good permeability, and has low potential for efflux. [C.]
In vivo	In the muscle, PPARδ (30, 100 mg/kg) enhances target gene transcription.

Chemical Properties

Molecular Weight	476.49
Formula	C25H27F3N2O4
Cas No.	2095128-17-7

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 40 mg/mL (83.95 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0987 mL	10.4934 mL	20.9868 mL	104.9340 mL
5 mM	0.4197 mL	2.0987 mL	4.1974 mL	20.9868 mL
10 mM	0.2099 mL	1.0493 mL	2.0987 mL	10.4934 mL
20 mM	0.1049 mL	0.5247 mL	1.0493 mL	5.2467 mL
50 mM	0.0420 mL	0.2099 mL	0.4197 mL	2.0987 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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