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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $147 | In Stock | |
5 mg | $313 | In Stock | |
10 mg | $528 | In Stock | |
25 mg | $859 | In Stock | |
50 mg | $1,190 | In Stock | |
100 mg | $1,580 | In Stock | |
1 mL x 10 mM (in DMSO) | $329 | In Stock |
Description | MA-0204 is a highly selective and orally available peroxisome proliferator-activated receptor δ (PPARδ) modulator (EC50s: 0.4 nM, 7.9 nM and 10 nM for human, mouse and rat PPARδ, respectively). It is a potential treatment for Duchene Muscular Dystrophy (DMD). |
Targets&IC50 | PPARδ:7.9 nM (EC50)(in mouse), PPARδ:10 nM (EC50)(in rat), PPARδ:0.4 nM (EC50)(in human) |
In vitro | MA-0204 is >10,000-fold selective for activating PPARδ over PPARα and PPARγ receptors. At concentrations of 1.2-12 nM, MA-0204 enhances fatty acid oxidation in muscle myoblasts from DMD patients in mice, shows high protein binding in mouse plasma, exhibits good permeability, and has low potential for efflux. [C.] |
In vivo | In the muscle, PPARδ (30, 100 mg/kg) enhances target gene transcription. |
Molecular Weight | 476.49 |
Formula | C25H27F3N2O4 |
Cas No. | 2095128-17-7 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
Solubility Information | DMSO: 40 mg/mL (83.95 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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