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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $36 | In Stock | |
2 mg | $51 | In Stock | |
5 mg | $80 | In Stock | |
10 mg | $128 | In Stock | |
25 mg | $252 | In Stock | |
50 mg | $449 | In Stock | |
100 mg | $659 | In Stock | |
1 mL x 10 mM (in DMSO) | $89 | In Stock |
Description | ML311 is a selective inhibitor of the Mcl-1/Bim interaction. |
In vitro | ML311 potently halts the viability of several Mcl-1 primed cells, including MCL-1-1780 (EC50: 0.31 μM), NCI-H929 (EC50: 1.6 μM), and DHL-6 (EC50: 3.3 μM), with a high maximal effect (>80%). Additionally, ML311 displays activity in a leukemia-derived cell line reliant on Bcl-2 function (Bcl2-1863, EC50: 1.1 μM). ML311 exhibits strong growth inhibitory effects in numerous cell lines, with GI50<900 nM for nine cell types (RPMI-8226, SR, NCI-H322M, NCI-H60, HCC-2998, KM12, SF-295, U251, PC-3), and <2 μM for 14 additional types[1]. |
Molecular Weight | 415.45 |
Formula | C23H24F3N3O |
Cas No. | 315698-17-0 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 50 mg/mL (120.35 mM) ![]() H2O: Insoluble Ethanol: 20 mg/mL | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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