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ML311

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Purity:99.75%

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COA HPLC HNMR

ML311

Catalog No. T5108Cas No. 315698-17-0

ML311 is a selective inhibitor of the Mcl-1/Bim interaction.

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Pack Size	Price	Availability
1 mg	$36	In Stock
2 mg	$51	In Stock
5 mg	$80	In Stock
10 mg	$128	In Stock
25 mg	$252	In Stock
50 mg	$449	In Stock
100 mg	$659	In Stock
1 mL x 10 mM (in DMSO)	$89	In Stock

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Product Introduction

Bioactivity

Description

ML311 is a selective inhibitor of the Mcl-1/Bim interaction.

In vitro

ML311 potently halts the viability of several Mcl-1 primed cells, including MCL-1-1780 (EC50: 0.31 μM), NCI-H929 (EC50: 1.6 μM), and DHL-6 (EC50: 3.3 μM), with a high maximal effect (>80%). Additionally, ML311 displays activity in a leukemia-derived cell line reliant on Bcl-2 function (Bcl2-1863, EC50: 1.1 μM). ML311 exhibits strong growth inhibitory effects in numerous cell lines, with GI50<900 nM for nine cell types (RPMI-8226, SR, NCI-H322M, NCI-H60, HCC-2998, KM12, SF-295, U251, PC-3), and <2 μM for 14 additional types[1].

Chemical Properties

Molecular Weight	415.45
Formula	C23H24F3N3O
Cas No.	315698-17-0

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 50 mg/mL (120.35 mM)

H2O: Insoluble

Ethanol: 20 mg/mL

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4070 mL	12.0351 mL	24.0703 mL	120.3514 mL
5 mM	0.4814 mL	2.4070 mL	4.8141 mL	24.0703 mL
10 mM	0.2407 mL	1.2035 mL	2.4070 mL	12.0351 mL
20 mM	0.1204 mL	0.6018 mL	1.2035 mL	6.0176 mL
50 mM	0.0481 mL	0.2407 mL	0.4814 mL	2.4070 mL
100 mM	0.0241 mL	0.1204 mL	0.2407 mL	1.2035 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc