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ML311

🥰Excellent
Catalog No. T5108Cas No. 315698-17-0

ML311 is a selective inhibitor of the Mcl-1/Bim interaction.

ML311

ML311

🥰Excellent
Purity: 99.75%
Catalog No. T5108Cas No. 315698-17-0
ML311 is a selective inhibitor of the Mcl-1/Bim interaction.
Pack SizePriceAvailabilityQuantity
1 mg34 €In Stock
2 mg48 €In Stock
5 mg76 €In Stock
10 mg121 €In Stock
25 mg239 €In Stock
50 mg426 €In Stock
100 mg626 €In Stock
1 mL x 10 mM (in DMSO)84 €In Stock
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Purity:99.75%
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Product Introduction

Bioactivity
Description
ML311 is a selective inhibitor of the Mcl-1/Bim interaction.
In vitro
ML311 potently halts the viability of several Mcl-1 primed cells, including MCL-1-1780 (EC50: 0.31 μM), NCI-H929 (EC50: 1.6 μM), and DHL-6 (EC50: 3.3 μM), with a high maximal effect (>80%). Additionally, ML311 displays activity in a leukemia-derived cell line reliant on Bcl-2 function (Bcl2-1863, EC50: 1.1 μM). ML311 exhibits strong growth inhibitory effects in numerous cell lines, with GI50<900 nM for nine cell types (RPMI-8226, SR, NCI-H322M, NCI-H60, HCC-2998, KM12, SF-295, U251, PC-3), and <2 μM for 14 additional types[1].
Chemical Properties
Molecular Weight415.45
FormulaC23H24F3N3O
Cas No.315698-17-0
SmilesCCN1CCN(CC1)C(c1ccc(cc1)C(F)(F)F)c1ccc2cccnc2c1O
Relative Density.1.268 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 50 mg/mL (120.35 mM)
H2O: Insoluble
Ethanol: 20 mg/mL
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.4070 mL12.0351 mL24.0703 mL120.3514 mL
5 mM0.4814 mL2.4070 mL4.8141 mL24.0703 mL
10 mM0.2407 mL1.2035 mL2.4070 mL12.0351 mL
20 mM0.1204 mL0.6018 mL1.2035 mL6.0176 mL
50 mM0.0481 mL0.2407 mL0.4814 mL2.4070 mL
100 mM0.0241 mL0.1204 mL0.2407 mL1.2035 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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