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NCT-505

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NCT-505

Catalog No. T12196Cas No. 2231079-74-4

NCT-505 is a potent and selective inhibitor of aldehyde dehydrogenase (ALDH1A1, IC50 = 7 nM) and a weak inhibitor of hALDH1A2, hALDH1A3, hALDH2, hALDH3A1 with IC50 values of >57 μM, 22.8 μM, 20.1 μM, >57 μM respectively.

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Pack Size	Price	Availability
1 mg	$195	In Stock
5 mg	$413	In Stock
10 mg	$618	In Stock
25 mg	$985	In Stock
50 mg	$1,330	In Stock
100 mg	$1,790	In Stock
1 mL x 10 mM (in DMSO)	$475	In Stock

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Product Introduction

Bioactivity

Description

In vitro

NCT-505 (compound 86) is a potent and selective aldehyde dehydrogenase (ALDH1A1) inhibitor with IC50 of 7 nM, weakly inhibits hALDH1A2, hALDH1A3, hALDH2, hALDH3A1 (IC50s, >57, 22.8, 20.1, >57 μM ). NCT-505 has no significant inhibitory effect on 5-hydroxyprostaglandin dehydrogenase (HPGD) and type 4 hydroxysteroid dehydrogenase (HSD17β4) (IC50, >57 μM). In addition, NCT-505 showed potent cellular viability, reducing the viability of OV-90 cells with EC50 of 2.10-3.92 μM. NCT-505 is also cytotoxic to SKOV-3-TR cells with IC50 of 1, 3, 10, 20, 30 μM in titration analysis[1].

Chemical Properties

Molecular Weight	521.61
Formula	C27H28FN5O3S
Cas No.	2231079-74-4

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55 mg/ml (105.44 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9171 mL	9.5857 mL	19.1714 mL	95.8571 mL
5 mM	0.3834 mL	1.9171 mL	3.8343 mL	19.1714 mL
10 mM	0.1917 mL	0.9586 mL	1.9171 mL	9.5857 mL
20 mM	0.0959 mL	0.4793 mL	0.9586 mL	4.7929 mL
50 mM	0.0383 mL	0.1917 mL	0.3834 mL	1.9171 mL
100 mM	0.0192 mL	0.0959 mL	0.1917 mL	0.9586 mL

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In Vivo Formulation Calculator (Clear solution)

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

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mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc