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Nestoron

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Purity:99.83%

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COA HNMR HPLC

Nestoron

Catalog No. T5174Cas No. 7759-35-5

Nestoron (Segesterone Acetate), a synthetic progestin, is a high-affinity agonist of the progesterone receptor (EC50: 10.3 nM).

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Pack Size	Price	Availability
5 mg	$35	In Stock
10 mg	$57	In Stock
25 mg	$118	In Stock
50 mg	$226	In Stock
100 mg	$365	In Stock
1 mL x 10 mM (in DMSO)	$63	In Stock

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Product Introduction

Bioactivity

Description	Nestoron (Segesterone Acetate), a synthetic progestin, is a high-affinity agonist of the progesterone receptor (EC50: 10.3 nM).
Targets&IC50	PR:10.3 nM
In vitro	Nestorone (ST-1435) showed significant binding (ED50 = 56 nM) compared to the binding of dexamethasone (ED50 = 21 nM) to calf thymus GR. Progesterone and Nestorone showed no binding to SHBG [1]. Chronic ST-1435 and E2 alone or in combination increased neurogenesis by a comparable magnitude, with minimum to no antagonistic or additive effects between ST-1435 and E2. In addition, chronic exposure of ST-1435 or ST-1435 + E2 stimulated oligodendrocyte generation [2].
In vivo	The potency of Nestorone was over 100-fold higher upon s.c. administration than via the oral route. Nestorone showed no androgenic or anabolic activity. Nestorone did not bind to sex hormone binding globulin (SHBG). In contrast to estradiol and levonorgestrel, Nestorone showed no uterotropic activity in ovariectomized rats. Despite significant binding to glucocorticoid receptors (GR), Nestorone showed no glucocorticoid activity in vivo [1].
Animal Research	Immature female rats were ovariectomized under methoxylflurane anesthesia, randomly distributed into treatment groups (n 5 6 per group), and used 5 to 7 days later. Levonorgestrel or Nestorone (1 or 5 mg) was injected s.c. daily for 5 days. Vaginal lavages were examined microscopically to detect vaginal cornification. The animals were killed on day 6, and the uteri were removed, cleaned, blotted dry, and weighed. The antiestrogenic effects of levonorgestrel and Nestorone were determined in rats receiving 1.0 mg E2. A positive control group received E2 alone. Negative controls received the vehicle [1].
Alias	ST-1435, Segesterone Acetate, Nestorone, Elcometrine

Chemical Properties

Molecular Weight	370.48
Formula	C23H30O4
Cas No.	7759-35-5

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 55 mg/mL (148.46 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6992 mL	13.4960 mL	26.9920 mL	134.9601 mL
5 mM	0.5398 mL	2.6992 mL	5.3984 mL	26.9920 mL
10 mM	0.2699 mL	1.3496 mL	2.6992 mL	13.4960 mL
20 mM	0.1350 mL	0.6748 mL	1.3496 mL	6.7480 mL
50 mM	0.0540 mL	0.2699 mL	0.5398 mL	2.6992 mL
100 mM	0.0270 mL	0.1350 mL	0.2699 mL	1.3496 mL

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