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Netivudine
Catalog No. T60540Cas No. 84558-93-0
Netivudine is a potent nucleoside reverse transcriptase inhibitor (NRTIs), a nucleoside analogue with anti-varicella zoster virus activity that can be used to treat human immunodeficiency virus (HIV) infection. Netivudine works by inhibiting reverse transcriptase, which reduces viral load in the body and slows the progression of the disease through its inhibitory effect.
Netivudine
Catalog No. T60540Cas No. 84558-93-0
Netivudine is a potent nucleoside reverse transcriptase inhibitor (NRTIs), a nucleoside analogue with anti-varicella zoster virus activity that can be used to treat human immunodeficiency virus (HIV) infection. Netivudine works by inhibiting reverse transcriptase, which reduces viral load in the body and slows the progression of the disease through its inhibitory effect.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $258 | In Stock | |
| 5 mg | $642 | In Stock | |
| 10 mg | $913 | In Stock | |
| 25 mg | $1,370 | In Stock | |
| 50 mg | $1,850 | In Stock | |
| 100 mg | $2,500 | In Stock | |
| 500 mg | $4,900 | In Stock |
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CitedSelect Batch
Purity:99.83%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Netivudine is a potent nucleoside reverse transcriptase inhibitor (NRTIs), a nucleoside analogue with anti-varicella zoster virus activity that can be used to treat human immunodeficiency virus (HIV) infection. Netivudine works by inhibiting reverse transcriptase, which reduces viral load in the body and slows the progression of the disease through its inhibitory effect. |
| Targets&IC50 | VZV:0.6-3.8μM |
| In vitro | The phosphorylation of netivudine in VZV infected human cells is similar to that of sorivudine and the IC50 of netivudine for VZV ranges from 06-3.8 uM. Since, in HSV-infected cells, only the monophosphate is formed, netivudine shows no appreciable in vitro activity against HSV or other human herpesviruses.[1] |
| In vivo | The half-life of netivudine in humans is about 12-15 hand preliminary pharmacokinetic studies, employing oral doses of netivudine at 100 mg, 200 mg and 400 mg in young adults and healthy elderly volunteers, confirmed that concentrations of the drug substantially above the IC50 for VZV could be achieved and sustained with twice daily dosing.[2] The drug bioavailability was 21.1% and 24.6% in the young and elderly, respectively. An initial, open, dose-ranging study of netivudine in 31 elderly immunocompetent patients with localised herpes zoster with oral doses up to 200mg twice daily showed therapeutic benefits upon rash healing and pain and no significant adverse effects.[3] |
| Molecular Weight | 282.25 |
| Formula | C12H14N2O6 |
| Cas No. | 84558-93-0 |
Storage & Solubility Information
| Storage | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 55 mg/mL (194.86 mM)  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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