Powder: -20°C for 3 years | In solvent: -80°C for 1 year
NF-κΒ Activator 2 is a potent, orally active compound that efficiently activates NF-κB with an EC50 value of 1.58 μM. By enhancing NF-κB expression and activation, it induces SOD 2 synthesis, rendering it useful for amyotrophic lateral sclerosis (ALS) research [1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 158.00 | |
5 mg | In stock | $ 397.00 | |
10 mg | In stock | $ 589.00 | |
25 mg | In stock | $ 945.00 | |
50 mg | In stock | $ 1,280.00 | |
100 mg | In stock | $ 1,730.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 437.00 |
Description | NF-κΒ Activator 2 is a potent, orally active compound that efficiently activates NF-κB with an EC50 value of 1.58 μM. By enhancing NF-κB expression and activation, it induces SOD 2 synthesis, rendering it useful for amyotrophic lateral sclerosis (ALS) research [1]. |
Targets&IC50 | NF-κB:1.58 μM (EC50) |
In vitro | NF-κB activator 2 (Compound 61) (1 μM, 6 hr) induces SOD 2 mRNA expression in SH-SY5Y neuroblastoma cells [1]. SOD2 is a highly inducible SOD that performs in concurrence with SOD1 to detoxify ROS. Induction of SOD2 can be obtained through the activation of NF-ҡBs. |
In vivo | NF-κΒ activator 2, when administered intravenously (i.v.) at a dose of 1 mg/kg, demonstrates an appropriate half-life of 0.96 hours in mice [1]. Similarly, at an oral (p.o.) dosage of 5 mg/kg, it shows a comparable half-life of 2.86 hours, an oral bioavailability of 15.6%, and a maximum concentration (C max) of 92 ng/mL [1]. |
Molecular Weight | 298.27 |
Formula | C16H11FN2O3 |
CAS No. | 2375281-44-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 250 mg/mL (838.17 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
NF-κΒ activator 2 2375281-44-8 NF-Κb NF-κB Nuclear factor-kappaB ALS amyotrophic Nuclear factor-κB lateral NF κΒ activator 2 NFκΒ activator 2 NF-?B Inhibitor SOD2 sclerosis NF-kb activator 2 inhibit NF-kappabeta activator 2 inhibitor