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Nicorandil

Nicorandil
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Purity:99.44%
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Nicorandil

Catalog No. T0075Cas No. 65141-46-0
Nicorandil (SG-75)(Ikorel) acts by relaxing the smooth muscle of the blood vessels, especially those of the venous system. It undertakes this through two methods. Firstly, by activating potassium channels, and secondly by donating nitric oxide to activate the enzyme guanylate cyclase. Guanylate cyclase causes activation of cGMP leading to both arterial and venous vasodilatation by de-phosphorylation of the myosin light chain.
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Pack SizePriceAvailabilityQuantity
50 mg$36In Stock
100 mg$51In Stock
200 mg$72In Stock
1 mL x 10 mM (in DMSO)$55In Stock
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Product Introduction

Bioactivity
Description
Nicorandil (SG-75)(Ikorel) acts by relaxing the smooth muscle of the blood vessels, especially those of the venous system. It undertakes this through two methods. Firstly, by activating potassium channels, and secondly by donating nitric oxide to activate the enzyme guanylate cyclase. Guanylate cyclase causes activation of cGMP leading to both arterial and venous vasodilatation by de-phosphorylation of the myosin light chain.
In vitro
Nicorandil (100 mM) increases Flavoprotein oxidation but not membrane current; a 10-fold higher concentration recruits both mitoK(ATP) and surfaceK(ATP) channels. Nicorandil bluntes the rate of cell death in a pelleting model of ischemia; this cardioprotective effect is prevented by the mitoK(ATP) channel blocker 5-hydroxydecanoate but is unaffected by the surfaceK(ATP) channel blocker HMR1098. [1] Nicorandil (100 mM) suppresses TUNEL positivity, cytochrome c translocation, caspase-3 activation and dissipation of mitochondrialinner membrane potential (Delta(Psi)(m)). Nicorandil prevents Delta(Psi)(m) depolarization in a concentration-dependent manner (EC(50) approximately 40 mM, with saturation by 100 mM), as shown by fluorescence-activated cell sorter analysis of cells stained with a fluorescent Delta(Psi)(m)-indicator, tetramethylrhodamine ethyl ester (TMRE). [2] Nicorandil activates a weakly inwardly-rectifying, glibenclamide-sensitive 80 pS K+ channel in both the transfected cells. Nicorandil preferentially activates the K(ATP) channels containing SUR2B in HEK293T cells. [3] Nicorandil (100 mM) significantly suppresses the number of cells with TUNEL-positive nuclei and the increase in caspase-3 activity induced by 20 mM Water2. Nicorandil prevents the loss of DeltaPsim induced by Water2 in a concentration-dependent manner. [4]
AliasSG-75
Chemical Properties
Molecular Weight211.17
FormulaC8H9N3O4
Cas No.65141-46-0
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
H2O: 80.5 mM
DMSO: 50 mg/mL (236.76 mM)
Solution Preparation Table
DMSO/H2O
1mg5mg10mg50mg
1 mM4.7355 mL23.6776 mL47.3552 mL236.7761 mL
5 mM0.9471 mL4.7355 mL9.4710 mL47.3552 mL
10 mM0.4736 mL2.3678 mL4.7355 mL23.6776 mL
20 mM0.2368 mL1.1839 mL2.3678 mL11.8388 mL
50 mM0.0947 mL0.4736 mL0.9471 mL4.7355 mL
DMSO
1mg5mg10mg50mg
100 mM0.0474 mL0.2368 mL0.4736 mL2.3678 mL

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