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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $84 | In Stock | |
5 mg | $198 | In Stock | |
10 mg | $297 | In Stock | |
25 mg | $538 | In Stock | |
50 mg | $753 | In Stock | |
100 mg | $987 | In Stock | |
1 mL x 10 mM (in DMSO) | $229 | In Stock |
Description | NS 11021 (NS11021) , a novel opener of large-conductance Ca(2+)-activated K(+) channels |
In vivo | NS11021 increased currents sensitive to the selective BK(Ca) channel blocker, iberiotoxin (IbTX) in SMCs, but did not modulate K(+) current in HUVECs.?NS11021 reduced [Ca(2+)](i) and tension in penile arteries.?IbTX inhibited the vasorelaxation induced by NS11021 and sildenafil in human erectile tissue.?NS11021 and sildenafil but not vehicle increased erectile responses in anaesthetized rats, an effect which was abolished after pretreatment with tetraethylammonium[1]. |
Alias | NS11021 |
Molecular Weight | 511.24 |
Formula | C16H9BrF6N6S |
Cas No. | 956014-19-0 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 250 mg/mL (489.01 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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