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NS 11021
Catalog No. T4294Cas No. 956014-19-0
NS 11021 (NS11021) , a novel opener of large-conductance Ca(2+)-activated K(+) channels
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $84 | In Stock | |
| 5 mg | $198 | In Stock | |
| 10 mg | $297 | In Stock | |
| 25 mg | $538 | In Stock | |
| 50 mg | $753 | In Stock | |
| 100 mg | $987 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $229 | In Stock |
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CitedProduct Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | NS 11021 (NS11021) , a novel opener of large-conductance Ca(2+)-activated K(+) channels |
| In vivo | NS11021 increased currents sensitive to the selective BK(Ca) channel blocker, iberiotoxin (IbTX) in SMCs, but did not modulate K(+) current in HUVECs.?NS11021 reduced [Ca(2+)](i) and tension in penile arteries.?IbTX inhibited the vasorelaxation induced by NS11021 and sildenafil in human erectile tissue.?NS11021 and sildenafil but not vehicle increased erectile responses in anaesthetized rats, an effect which was abolished after pretreatment with tetraethylammonium[1]. |
| Alias | NS11021 |
| Molecular Weight | 511.24 |
| Formula | C16H9BrF6N6S |
| Cas No. | 956014-19-0 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 250 mg/mL (489.01 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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