Shopping Cart

Remove All

Your shopping cart is currently empty

NS-638

Select Batch

Purity:98.44%

Resource Download

COA HNMR HPLC

NS-638

Catalog No. T3543Cas No. 150493-34-8

NS-638 is a Ca2+-channel blocker. It can block K+-stimulated intracellular Ca2+-elevation (IC50: 3.4 μM).

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Pack Size	Price	Availability
2 mg	$39	In Stock
5 mg	$80	In Stock
10 mg	$122	In Stock
25 mg	$239	In Stock
50 mg	$385	In Stock
100 mg	$522	In Stock
1 mL x 10 mM (in DMSO)	$72	In Stock

Bulk & Custom

Add to Cart

Questions

Related Compound Libraries of "NS-638"

Product Introduction

Bioactivity

Description	NS-638 is a Ca2+-channel blocker. It can block K+-stimulated intracellular Ca2+-elevation (IC50: 3.4 μM).
In vitro	NS-638 dose-dependently inhibits K+-stimulated [45 Ca2+]-uptake in chick cortical synaptosomes and 2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid (AMPA)- stimulated [3H]GABA-release from cultured cortical neurons (IC50: 2.3 and 4.3 μM), respectively. K+-stimulated intracellular Ca2+-elevation in cultured cerebellar granule cells is equipotently blocked (IC50: 3.4 μM). At this concentration, no effect on Ca2+-induced contractions in K+-depolarized guinea pig taenia coli is observed. NS-638 reversibly blocks N- and L-type Ca2+-channels in cultured chick dorsal root ganglion cells (1-30 μM).
In vivo	In the mouse model of middle cerebral artery occlusion, NS-638 administration (50 mg/kg, i.p.) at 1 hour and 6 hours after ischemia, followed by daily dosing for two subsequent days, leads to a 48% decrease in overall infarct volume. However, it fails to demonstrate neuroprotective effects in the gerbil model of bilateral carotid artery occlusion against ischemic neuronal damage.
Cell Research	NS-638 is prepared in 1% DMSO and 1% ethanol. The effect of NS-638 on neuronal Ca2+-channels is evaluated using whole cell patch clamp techniques[1].
Alias	NS 638

Chemical Properties

Molecular Weight	325.72
Formula	C15H11ClF3N3
Cas No.	150493-34-8

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55 mg/mL (168.86 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0701 mL	15.3506 mL	30.7012 mL	153.5061 mL
5 mM	0.6140 mL	3.0701 mL	6.1402 mL	30.7012 mL
10 mM	0.3070 mL	1.5351 mL	3.0701 mL	15.3506 mL
20 mM	0.1535 mL	0.7675 mL	1.5351 mL	7.6753 mL
50 mM	0.0614 mL	0.3070 mL	0.6140 mL	3.0701 mL
100 mM	0.0307 mL	0.1535 mL	0.3070 mL	1.5351 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc