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NV-5138
🥰Excellent
Catalog No. T12270Cas No. 2095886-80-7
NV-5138 is a selective, orally active intracerebral mTORC1 agonist that binds to Sestrin2. It is a leucine analog. It can be used in biological studies of antidepressants.
NV-5138
🥰Excellent
Purity: 99.74%
Catalog No. T12270Cas No. 2095886-80-7
NV-5138 is a selective, orally active intracerebral mTORC1 agonist that binds to Sestrin2. It is a leucine analog. It can be used in biological studies of antidepressants.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | 86 € | In Stock | |
| 5 mg | 214 € | In Stock | |
| 10 mg | 344 € | In Stock | |
| 25 mg | 737 € | In Stock | |
| 50 mg | 1.168 € | In Stock | |
| 100 mg | 1.691 € | In Stock |
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Purity:99.74%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | NV-5138 is a selective, orally active intracerebral mTORC1 agonist that binds to Sestrin2. It is a leucine analog. It can be used in biological studies of antidepressants. |
| In vivo | METHODS: Rats were orally administered NV-5138 (40, 80 or 160 mg/kg), and behavioral tests were started 24 hours later, including behavioral despair test (forced swimming test FST) and anxiety test (novelty suppression feeding test NSFT). In FST and NSFT, analyzes were performed 1 or 3 days after dosing. RESULTS NV-5138 significantly reduced immobility time and feeding latency, respectively, at 160 mg/kg but not at 40 or 80 mg/kg. [1] METHODS: To test the duration of the antidepressant effect of NV-5138, rats were orally administered NV-5138 (160 mg/kg) and behavioral tests were started after 3 and 7 days or daily administration for 7 days (starting on day 0 ) of lower doses of NV-5138 (40 or 80 mg/kg, oral) RESULTS NV-5138 significantly reduced immobility time at both 3 and 7 days after FST administration; NV-5138 produced antidepressant effects at repeated low doses of NV-5138 (80mg/kg). [1] |
| Molecular Weight | 181.18 |
| Formula | C7H13F2NO2 |
| Cas No. | 2095886-80-7 |
| Smiles | CC(C)(C[C@H](N)C(O)=O)C(F)F |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
| Solubility Information | DMSO: 1.81 mg/ml (10 mM)  | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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