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Ondansetron hydrochloride dihydrate

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Purity:99.71%

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COA HPLC LCMS HNMR

Ondansetron hydrochloride dihydrate

Catalog No. T1478Cas No. 103639-04-9

Ondansetron hydrochloride dihydrate (GR 38032) is a competitive serotonin type 3 receptor antagonist. It is effective in the treatment of nausea and vomiting caused by cytotoxic chemotherapy drugs, including cisplatin, and has reported anxiolytic and neuroleptic properties.

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25 mg	$36	In Stock
50 mg	$46	In Stock
100 mg	$55	In Stock
200 mg	$68	In Stock

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Product Introduction

Bioactivity

Description	Ondansetron hydrochloride dihydrate (GR 38032) is a competitive serotonin type 3 receptor antagonist. It is effective in the treatment of nausea and vomiting caused by cytotoxic chemotherapy drugs, including cisplatin, and has reported anxiolytic and neuroleptic properties.
In vitro	Ondansetron is a potent, highly selective, competitive antagonist at 5-HT3 receptors. It demonstrates some affinity to other receptor subtypes, including 5-HT1B, 5-HT1C, 5-HT4, opioid, and 1-adrenergic receptors, and to the μ-opioid receptor. However, ondansetron has 1000:1 selectivity toward 5-HT3 receptors[1]. Ondansetron is found to be the most potent HERG-channel blocker among several 5-HT3 antagonists, with an IC50 of 810 nM and has been reported to block Na+ channels[2].
In vivo	Ondansetron(Ond) is well tolerated and its side effects are mild. Ond acts on the CNS as well as on the peripheral nervous system (PNS). Ondansetron is available both for oral and intravenous administration. The bioavailability of orally administered ondansetron is only 60%. The low bioavailability is due to a significant first-pass metabolism. The peak plasma concentration of ondansetron is usually reached at approximately 1.5 h after oral administration. A major portion of this drug, about 75%, is bound to plasma proteins. Ondansetron is currently used to prevent and treat nausea and vomiting associated with chemotherapy, radiation treatment and general anesthesia. It has been shown to inhibit GABA and glycine receptor activity in animal models[1]. Therapeutic dose of Ond allows delivery of significantly higher amounts of Dox to the brain tissue in vivo, which is otherwise disallowed by the BBB. The rate of penetration of the blood-brain barrier by Ond is very low[3].
Cell Research	Cells are plated in 60-mm Petri dishes (2×105 per dish) and cultured in serumcontained medium for 24 h. The next day the medium is removed and serum-contained medium with or without Dox (0.1 or 0.5 μg/ml) and Ond (10 or 30 μg/ml) in combination or respectively, is added. After 3 days, the cells are washed twice with PBS, trypsinized, and counted by using the trypan blue exclusion method.(Only for Reference)
Alias	SN 307, NSC 665799, GR 38032, Ondansetron hydrochloride

Chemical Properties

Molecular Weight	365.86
Formula	C18H19N3O·HCl·2H2O
Cas No.	103639-04-9

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 38 mg/mL (103.9 mM)

H2O: 67 mg/mL (183.1 mM)

DMSO: 10 mg/mL (27.33 mM)

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7333 mL	13.6664 mL	27.3329 mL	136.6643 mL
5 mM	0.5467 mL	2.7333 mL	5.4666 mL	27.3329 mL
10 mM	0.2733 mL	1.3666 mL	2.7333 mL	13.6664 mL
20 mM	0.1367 mL	0.6833 mL	1.3666 mL	6.8332 mL

H2O

	1mg	5mg	10mg	50mg
50 mM	0.0547 mL	0.2733 mL	0.5467 mL	2.7333 mL
100 mM	0.0273 mL	0.1367 mL	0.2733 mL	1.3666 mL

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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

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mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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Ondansetron hydrochloride dihydrate

Ondansetron hydrochloride dihydrate

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