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OTUB1/USP8-IN-1
OTUB1/USP8-IN-1 is a potent OTUB1/USP8 inhibitor with potential anticancer activity, demonstrating IC50 values of 0.17 nM for OTUB1 and 0.28 nM for USP8. OTUB1/USP8-IN-1 can be used in the study of non-small-cell lung cancer.
Catalog No. T72784Cas No. 2858800-98-1
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Purity:98.63%
ee:100%
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OTUB1/USP8-IN-1
Catalog No. T72784Cas No. 2858800-98-1
OTUB1/USP8-IN-1 is a potent OTUB1/USP8 inhibitor with potential anticancer activity, demonstrating IC50 values of 0.17 nM for OTUB1 and 0.28 nM for USP8. OTUB1/USP8-IN-1 can be used in the study of non-small-cell lung cancer.
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Product Introduction
Bioactivity
Chemical Properties
| Description | OTUB1/USP8-IN-1 is a potent OTUB1/USP8 inhibitor with potential anticancer activity, demonstrating IC50 values of 0.17 nM for OTUB1 and 0.28 nM for USP8. OTUB1/USP8-IN-1 can be used in the study of non-small-cell lung cancer. |
| Targets&IC50 | A549 cells:1004 nM, EBC-1:172 nM, H23:431 nM, H1703:145 nM, H1975 (EGFR):118 nM |
| In vitro | OTUB1/USP8-IN-1 (10 nM-10 μM; 72 hours) inhibited the proliferation of H1975, H1703, EBC-1, H23, and A549 cells with IC50 values of 118, 145, 172, 431, and 1004 nM, respectively[1]. |
| In vivo | OTUB1/USP8-IN-1 (5 mg/kg; intraperitoneal injection; QD and BID, for 2 weeks) reduced the total tumor weight and average tumor volume in BALB/c nude mice by over twofold with BID dosing[1]. |
| Molecular Weight | 426.83 |
| Formula | C22H16ClFN2O4 |
| Cas No. | 2858800-98-1 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 30 mg/mL (70.29 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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