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PD-166793
PD-166793 is an orally active, potent and selective MMP inhibitor with inhibitory effects on MMP-2, MMP-3 and MMP-13.PD-166793 ameliorates myocardial ischemia and reperfusion injury in a rat model of heart failure.PD-166793 is an orally active, potent and selective MMP inhibitor with inhibitory effects on MMP-2, MMP-3, and MMP-13.
Catalog No. T20563Cas No. 199850-67-4
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Purity:100%
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PD-166793
Catalog No. T20563Alias PD-166793-0000, PD166793, PD 166793Cas No. 199850-67-4
PD-166793 is an orally active, potent and selective MMP inhibitor with inhibitory effects on MMP-2, MMP-3 and MMP-13.PD-166793 ameliorates myocardial ischemia and reperfusion injury in a rat model of heart failure.PD-166793 is an orally active, potent and selective MMP inhibitor with inhibitory effects on MMP-2, MMP-3, and MMP-13.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $52 | In Stock | |
| 500 mg | $1,430 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | PD-166793 is an orally active, potent and selective MMP inhibitor with inhibitory effects on MMP-2, MMP-3 and MMP-13.PD-166793 ameliorates myocardial ischemia and reperfusion injury in a rat model of heart failure.PD-166793 is an orally active, potent and selective MMP inhibitor with inhibitory effects on MMP-2, MMP-3, and MMP-13. |
| Targets&IC50 | MMP9:7.9 μM, MMP1:6.0 μM, MMP13:8 nM, MMP2:4 nM, MMP7:7.2 μM, MMP3:7 nM |
| In vitro | In rat heart homogenates, PD-166793 at a concentration of 0.1 μM results in a 20% inhibition of AMP deaminase (AMPD) activity[2]. Additionally, when normal human cardiac fibroblasts are treated with PD-166793 at a concentration of 100 μM for 36 hours, there is a significant reduction in MMP‐9 activity[1]. |
| In vivo | Administered at a dosage of 1 mg/kg per day through daily gavage for a duration of 10 weeks, PD-166793 largely prevents the adverse remodeling typically observed in the aortocaval (AV) fistula model[3]. Furthermore, in rats, PD-166793 administered at a dose of 5 mg/kg via oral gavage demonstrates superior pharmacokinetics, with a half-life (t1/2) of 43.6 hours, a maximum concentration (Cmax) of 42.4 µg/mL, and an area under the curve from 0 to infinity (AUC0-∞) of 2822 µg•h/mL[2]. |
| Alias | PD-166793-0000, PD166793, PD 166793 |
| Molecular Weight | 412.3 |
| Formula | C17H18BrNO4S |
| Cas No. | 199850-67-4 |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 45 mg/mL (109.14 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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