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Pack Size | Price | Availability | Quantity |
---|---|---|---|
2 mg | $51 | In Stock | |
5 mg | $82 | In Stock | |
10 mg | $124 | In Stock | |
25 mg | $224 | In Stock | |
50 mg | $332 | In Stock | |
100 mg | $497 | In Stock | |
200 mg | $678 | In Stock | |
1 mL x 10 mM (in DMSO) | $97 | In Stock |
Description | Perhexiline maleate is an orally active inhibitor of CPT1 and CPT2, reducing fatty acid metabolism, with IC50 values of 77 μM and 148 μM against rat heart and liver CPT1, respectively. |
Targets&IC50 | CPT1 (rat liver):148 μM (IC50), CPT1 (rat heart):77 μM (IC50) |
In vitro | Perhexiline treatment increases the susceptibility of NB cells to antiblastic treatments. Co-administration of Perhexiline maleate potentiates the efficacy of cisplatin to reduce the in vitro clonogenic potential of NB cells[2]. |
In vivo | The co-administration of Perhexiline and cisplatin yields a clear enhancement of antitumor effects, resulting in a significantly improved progression-free survival as compared with mice treated with DMSO. |
Molecular Weight | 393.56 |
Formula | C23H39NO4 |
Cas No. | 6724-53-4 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
Solubility Information | DMSO: 27.5 mg/mL (69.87 mM) ![]() | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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