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PF-04979064
PF-04979064 is a potent and selective PI3K and mTOR dual kinase inhibitor, with Ki values of 0.13 nM and 1.42 nM, respectively.
Catalog No. T7343Cas No. 1220699-06-8
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Purity:98.04%
ee:96.72%
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PF-04979064
Catalog No. T7343Cas No. 1220699-06-8
PF-04979064 is a potent and selective PI3K and mTOR dual kinase inhibitor, with Ki values of 0.13 nM and 1.42 nM, respectively.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $31 | In Stock | |
| 10 mg | $53 | In Stock | |
| 25 mg | $107 | In Stock | |
| 50 mg | Inquiry | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | PF-04979064 is a potent and selective PI3K and mTOR dual kinase inhibitor, with Ki values of 0.13 nM and 1.42 nM, respectively. |
| Targets&IC50 | PI3Kδ:0.122 nM (Ki) , PI3Kα:0.13 nM (Ki) , PI3Kγ:0.111 nM (Ki) , mTOR:1.42 nM (Ki) |
| In vivo | PF-04979064 was tested against human class I PI3K isoforms α, γ, and δ, with PI3Kα Ki of 0.130 nM, PI3Kγ Ki of 0.111 nM, and PI3Kδ Ki of 0.122 nM.PF-04979064 was progressed to rat in vivo PK studies and exhibited robust PK profile: Vdss = 5.23 L/kg, Cl = 19.3 mL/min/kg, T1/2 = 1.85 h, and F % = 61%. |
| Molecular Weight | 446.5 |
| Formula | C24H26N6O3 |
| Cas No. | 1220699-06-8 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
| Solubility Information | DMSO: 4.46 mg/mL (10 mM), Sonication is recommended.  | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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