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PF-06260933

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Purity:99.97%

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COA HPLC HNMR

PF-06260933

Catalog No. T4221Cas No. 1811510-56-1

PF-06260933 is a highly selective small-molecule MAP4K4 inhibitor with IC50s of 3.7 and 160 nM for kinase and cell, respectively.

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Pack Size	Price	Availability
1 mg	$42	In Stock
2 mg	$58	In Stock
5 mg	$105	In Stock
10 mg	$166	In Stock
25 mg	$342	In Stock
50 mg	$547	In Stock
100 mg	$789	In Stock
1 mL x 10 mM (in DMSO)	$105	In Stock

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Product Introduction

Bioactivity

Description	PF-06260933 is a highly selective small-molecule MAP4K4 inhibitor with IC50s of 3.7 and 160 nM for kinase and cell, respectively.
Targets&IC50	MAP4K4:3.7 nM
In vitro	Treatment with PF-06260933 significantly enhances the resistance of human aortic endothelial cells (EC) to TNF-α-induced increases in endothelial permeability in vitro.
In vivo	Treatment with PF-06260933 does not modify plasma lipid content in a mouse model, yet it leads to decreased glucose levels, mirroring outcomes seen in whole-body-inducible Map4k4 knockout animals. Moreover, PF-06260933 administration results in either the attenuation of plaque progression or promotion of plaque regression in this model (46.0% versus 25.5%), alongside reductions in both plasma glucose and lipid content.
Alias	PF-6260933, PF 6260933, PF6260933

Chemical Properties

Molecular Weight	296.75
Formula	C16H13ClN4
Cas No.	1811510-56-1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 50 mg/mL (168.49 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3698 mL	16.8492 mL	33.6984 mL	168.4920 mL
5 mM	0.6740 mL	3.3698 mL	6.7397 mL	33.6984 mL
10 mM	0.3370 mL	1.6849 mL	3.3698 mL	16.8492 mL
20 mM	0.1685 mL	0.8425 mL	1.6849 mL	8.4246 mL
50 mM	0.0674 mL	0.3370 mL	0.6740 mL	3.3698 mL
100 mM	0.0337 mL	0.1685 mL	0.3370 mL	1.6849 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc