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PF-5190457

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Purity:99.34%

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COA HPLC HNMR

PF-5190457

Catalog No. T16508Cas No. 1334782-79-4

PF-5190457 is an effective and selective ghrelin receptor inverse agonist (pKi: 8.36).

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Pack Size	Price	Availability
1 mg	$31	In Stock
2 mg	$44	In Stock
5 mg	$72	In Stock
10 mg	$128	In Stock
25 mg	$289	In Stock
50 mg	Inquiry	In Stock
1 mL x 10 mM (in DMSO)	$82	In Stock

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Product Introduction

Bioactivity

Description	PF-5190457 is an effective and selective ghrelin receptor inverse agonist (pKi: 8.36).
In vitro	PF-5190457 has a superior balance of ghrelin receptor pharmacology. It also has off-target selectivity [1].
In vivo	In human whole and dispersed islets, PF-5190457 has excellent selectivity and demonstrates robust increases in glucose-stimulated insulin secretion[1].
Alias	PF-05190457

Chemical Properties

Molecular Weight	512.67
Formula	C29H32N6OS
Cas No.	1334782-79-4

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 250 mg/mL (487.64 mM)

Ethanol: 100 mg/mL (195.06 mM)

Solution Preparation Table

DMSO/Ethanol

	1mg	5mg	10mg	50mg
1 mM	1.9506 mL	9.7529 mL	19.5057 mL	97.5286 mL
5 mM	0.3901 mL	1.9506 mL	3.9011 mL	19.5057 mL
10 mM	0.1951 mL	0.9753 mL	1.9506 mL	9.7529 mL
20 mM	0.0975 mL	0.4876 mL	0.9753 mL	4.8764 mL
50 mM	0.0390 mL	0.1951 mL	0.3901 mL	1.9506 mL
100 mM	0.0195 mL	0.0975 mL	0.1951 mL	0.9753 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

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