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PF-5190457
🥰Excellent
Catalog No. T16508Cas No. 1334782-79-4
Alias PF-05190457
PF-5190457 is an effective and selective ghrelin receptor inverse agonist (pKi: 8.36).
PF-5190457
🥰Excellent
Purity: 99.34%
Catalog No. T16508Alias PF-05190457Cas No. 1334782-79-4
PF-5190457 is an effective and selective ghrelin receptor inverse agonist (pKi: 8.36).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $31 | In Stock | |
| 2 mg | $44 | In Stock | |
| 5 mg | $72 | In Stock | |
| 10 mg | $128 | In Stock | |
| 25 mg | $289 | In Stock | |
| 50 mg | Inquiry | In Stock | |
| 1 mL x 10 mM (in DMSO) | $82 | In Stock |
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Purity:99.34%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | PF-5190457 is an effective and selective ghrelin receptor inverse agonist (pKi: 8.36). |
| Targets&IC50 | Ghrelin receptor:8.36 (pKi) |
| In vitro | PF-5190457 demonstrates an optimal balance of ghrelin receptor pharmacology along with off-target selectivity [1]. |
| In vivo | In human whole and dispersed islets, PF-5190457 has excellent selectivity and demonstrates robust increases in glucose-stimulated insulin secretion[1]. |
| Alias | PF-05190457 |
| Molecular Weight | 512.67 |
| Formula | C29H32N6OS |
| Cas No. | 1334782-79-4 |
| Smiles | Cc1cn2cc(CC(=O)N3CCC4(CN(C4)[C@@H]4CCc5cc(ccc45)-c4cc(C)ncn4)CC3)nc2s1 |
| Relative Density. | 1.41 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 250 mg/mL (487.64 mM), Sonication is recommended. Ethanol: 100 mg/mL (195.06 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
Ethanol/DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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