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Pluripotin (SC1) (SC1), which keep embryonic stem cell (ESC) self-renewal, is a dual inhibitor of extracellular signal-regulated kinase 1 (ERK1, MAPK3) and RasGAP.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $30 | In Stock | |
2 mg | $43 | In Stock | |
5 mg | $61 | In Stock | |
10 mg | $85 | In Stock | |
25 mg | $150 | In Stock | |
50 mg | $231 | In Stock | |
100 mg | $369 | In Stock | |
1 mL x 10 mM (in DMSO) | $72 | In Stock |
Description | Pluripotin (SC1) (SC1), which keep embryonic stem cell (ESC) self-renewal, is a dual inhibitor of extracellular signal-regulated kinase 1 (ERK1, MAPK3) and RasGAP. |
Targets&IC50 | RasGAP:212 nM(Kd), ERK1:98 nM(Kd) |
In vitro | Pluripotin is a dual function small molecule inhibitor of both ERK1 and RasGAP and that simultaneous inhibition of both protein activities is required and sufficient for Pluripotin's effects on mES cells. Pluripotin activates Ras by inhibition of RasGAP function[1]. Pluripotin improved the derivation efficiency and pluripotency of ES cells from C57BL/6. Three types of pluripotent stem cells (fES, ntES, and iPS cells) of the C57BL/6 background could generate full-term pups with high efficiency when cultured with Pluripotin[1]. |
Alias | SC1 |
Molecular Weight | 550.53 |
Formula | C27H25F3N8O2 |
Cas No. | 839707-37-8 |
Smiles | CN1C(=O)N(Cc2cnc(Nc3cc(C)nn3C)nc12)c1cc(NC(=O)c2cccc(c2)C(F)(F)F)ccc1C |
Relative Density. | 1.43 g/cm3 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
Solubility Information | DMSO: 13.8 mg/mL (25 mM) | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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