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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $30 | In Stock | |
2 mg | $43 | In Stock | |
5 mg | $61 | In Stock | |
10 mg | $85 | In Stock | |
25 mg | $150 | In Stock | |
50 mg | $231 | In Stock | |
100 mg | $369 | In Stock | |
1 mL x 10 mM (in DMSO) | $72 | In Stock |
Description | Pluripotin (SC1) (SC1), which keep embryonic stem cell (ESC) self-renewal, is a dual inhibitor of extracellular signal-regulated kinase 1 (ERK1, MAPK3) and RasGAP. |
In vitro | SC1 is a dual function small molecule inhibitor of both ERK1 and RasGAP and that simultaneous inhibition of both protein activities is required and sufficient for SC1's effects on mES cells. SC1 activates Ras by inhibition of RasGAP function[1]. SC1 improved the derivation efficiency and pluripotency of ES cells from C57BL/6. Three types of pluripotent stem cells (fES, ntES, and iPS cells) of the C57BL/6 background could generate full-term pups with high efficiency when cultured with SC1[1]. |
Alias | SC1 |
Molecular Weight | 550.53 |
Formula | C27H25F3N8O2 |
Cas No. | 839707-37-8 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||
Solubility Information | DMSO: 13.8 mg/mL (25 mM) | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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