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Ponatinib Hydrochloride

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Purity:100%

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COA HPLC HNMR

Ponatinib Hydrochloride

Catalog No. T2372LCas No. 1114544-31-8

Ponatinib Hydrochloride (AP-24534 Hydrochloride) is a hydrochloride of ponatinib. Ponatinib is an orally active multi-targeted kinase inhibitor with IC50s of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM, and 5.4 nM for Abl, PDGFRα, VEGFR2, FGFR1, and Src, respectively.

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Pack Size	Price	Availability
10 mg	$39	In Stock
25 mg	$72	In Stock
50 mg	$113	In Stock
100 mg	$172	In Stock
200 mg	$255	In Stock
500 mg	$433	In Stock

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Product Introduction

Bioactivity

Description	Ponatinib Hydrochloride (AP-24534 Hydrochloride) is a hydrochloride of ponatinib. Ponatinib is an orally active multi-targeted kinase inhibitor with IC50s of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM, and 5.4 nM for Abl, PDGFRα, VEGFR2, FGFR1, and Src, respectively.
Alias	AP 24534, AP-24534 Hydrochloride, AP-24534, Ponatinib hydrochloride, AP24534 Hydrochloride, AP24534

Chemical Properties

Molecular Weight	569.02
Formula	C29H28ClF3N6O
Cas No.	1114544-31-8

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 60 mg/mL (105.44 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7574 mL	8.7870 mL	17.5741 mL	87.8704 mL
5 mM	0.3515 mL	1.7574 mL	3.5148 mL	17.5741 mL
10 mM	0.1757 mL	0.8787 mL	1.7574 mL	8.7870 mL
20 mM	0.0879 mL	0.4394 mL	0.8787 mL	4.3935 mL
50 mM	0.0351 mL	0.1757 mL	0.3515 mL	1.7574 mL
100 mM	0.0176 mL	0.0879 mL	0.1757 mL	0.8787 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc