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Primin

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Purity:98.47%

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COA HPLC HNMR

Primin

Catalog No. TN2101Cas No. 15121-94-5

Primin is a natural product stored in trichomes on the leaves and stems of Primula obconica, exhibiting antimycobacterial and strong antineoplastic actions.

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Pack Size	Price	Availability
1 mg	$59	In Stock
5 mg	$137	In Stock
10 mg	$196	In Stock
25 mg	$335	In Stock
50 mg	$497	In Stock
100 mg	$723	In Stock
1 mL x 10 mM (in DMSO)	$150	In Stock

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Product Introduction

Bioactivity

Description	Primin is a natural product stored in trichomes on the leaves and stems of Primula obconica, exhibiting antimycobacterial and strong antineoplastic actions.
Targets&IC50	Leishmania donovani:0.711 μM, T. brucei rhodesiense:0.144 μM
In vitro	Primin showed very potent activity against Trypanosoma brucei rhodesiense (IC50 0.144 microM) and Leishmania donovani (IC50 0.711 microM), and revealed low cytotoxicity (IC50 15.4 microM) on mammalian cells. Only moderate inhibitory activity was observed against Mycobacterium tuberculosis, Trypanosoma cruzi, and Plasmodium falciparum. When tested for in vivo efficacy in a Trypanosoma b. brucei rodent model, Primin failed to cure the infection at 20 mg/kg given intraperitoneally. Primin was too toxic in vivo at a higher concentration (30 mg/kg, injected i.p. route) in mice infected with L. donovani.

Chemical Properties

Molecular Weight	208.25
Formula	C12H16O3
Cas No.	15121-94-5

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 60 mg/ml (288.12 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.8019 mL	24.0096 mL	48.0192 mL	240.0960 mL
5 mM	0.9604 mL	4.8019 mL	9.6038 mL	48.0192 mL
10 mM	0.4802 mL	2.4010 mL	4.8019 mL	24.0096 mL
20 mM	0.2401 mL	1.2005 mL	2.4010 mL	12.0048 mL
50 mM	0.0960 mL	0.4802 mL	0.9604 mL	4.8019 mL
100 mM	0.0480 mL	0.2401 mL	0.4802 mL	2.4010 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

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