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Pumosetrag Hydrochloride
🥰Excellent
Catalog No. T16683Cas No. 194093-42-0
Alias MKC-733, DDP-733
Pumosetrag Hydrochloride is an orally available 5-HT3 partial agonist. It is developed for the treatment of irritable bowel syndrome and gastroesophageal reflux disease.
Pumosetrag Hydrochloride
🥰Excellent
Catalog No. T16683Alias MKC-733, DDP-733Cas No. 194093-42-0
Pumosetrag Hydrochloride is an orally available 5-HT3 partial agonist. It is developed for the treatment of irritable bowel syndrome and gastroesophageal reflux disease.
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Product Introduction
Bioactivity
Chemical Properties
| Description | Pumosetrag Hydrochloride is an orally available 5-HT3 partial agonist. It is developed for the treatment of irritable bowel syndrome and gastroesophageal reflux disease. |
| In vivo | Pumosetrag modulates gastrointestinal activity by delaying liquid gastric emptying through proximal stomach relaxation and enhancing fasting antroduodenal migrating motor complex activity, while also speeding up small intestinal transit. Its effectiveness varies across different sections of the mouse intestine, displaying minimal to no activity. This compound demonstrates regional and species-specific responses, with reduced efficacy compared to 5-HT in the rat's jejunum, ileum, and distal colon, yet showing comparable efficacy and potency in the rat's proximal colon. In contrast, Pumosetrag is more potent and effective than 5-HT across all regions of the guinea pig intestine. Its mechanism, mediated by 5-HT(3) receptors, is confirmed by the inhibitory effect of ondansetron on its actions in rat and guinea pig tissues. |
| Alias | MKC-733, DDP-733 |
| Molecular Weight | 339.84 |
| Formula | C15H18ClN3O2S |
| Cas No. | 194093-42-0 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 30 mg/mL (88.28 mM), Sonication and heating are recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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