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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $33 | In Stock | |
5 mg | $74 | In Stock | |
10 mg | $113 | In Stock | |
25 mg | $201 | In Stock | |
50 mg | $305 | In Stock | |
100 mg | $497 | In Stock | |
1 mL x 10 mM (in DMSO) | $128 | In Stock |
Description | Pyridostatin Trifluoroacetate Salt is a G-quadruplexe stabilizer with Kd of 490 nM in a cell-free assay, which targets a series of proto-oncogenes including c-kit, K-ras and Bcl-2. |
Targets&IC50 | G-quadruplexe (Cell-free assay):490 nM(Kd) |
In vitro | Pyridostatin decreases the proliferation of MRC-5–SV40 cells and various cancer cell lines, and induces cell-cycle arrest by DNA-damage checkpoint activation. Pyridostatin also reduces SRC-dependent cell motility in MDA-MB-231 cells by interacting with G-quadruplex motifs in SRC.Pyridostatin decreases EBNA1 synthesis via inhibition of G-quadruplexes. |
Cell Research | Cell lines: MRC-5–SV40 cells and various cancer cell linesConcentrations: 10 μMIncubation Time: 48 hMethod: Cells are plated at equal confluence and are left either untreated or were treated with 2 μM pyridostatin continually during the indicated time before harvesting the cells. Cells from individual plates are trypsinized and counted in a Coulter counter. Graphs represent the total cell numbers at each time interval, and the error bars represent the s.e.m. Data represent three independent experiments. |
Molecular Weight | 938.71 |
Formula | C37H35F9N8O11 |
Cas No. | 1472611-44-1 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
Solubility Information | DMSO: 90 mg/mL (95.88 mM) | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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