Shopping Cart
- Remove All
![TargetMol](https://www.targetmol.com/storage/error/oops.webp)
Your shopping cart is currently empty
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $34 | In Stock | |
2 mg | $47 | In Stock | |
5 mg | $77 | In Stock | |
10 mg | $97 | In Stock | |
25 mg | $176 | In Stock | |
50 mg | $297 | In Stock | |
100 mg | $443 | In Stock | |
1 mL x 10 mM (in DMSO) | $85 | In Stock |
Description | Ravoxertinib (GDC-0994) is an efficacious, orally available ERK1/2 inhibitor with an IC50 of 1.1/0.3 nM. |
Targets&IC50 | ERK2:0.3 nM, ERK1:1.1 nM |
In vitro | GDC-0994 significantly inhibits phospho-p90RSK in tumor cells. |
In vivo | GDC-0994 (p.o.) inhibits intracellular ERK phosphorylation and activation of ERK-mediated signaling pathways, subsequently impeding the proliferation and survival of ERK-dependent tumor cells. In in vitro cancer models, GDC-0994 (p.o.) demonstrates significant single-dose efficacy, including against BRAF and KRAS mutant human xenograft tumors in mice. |
Alias | GDC-0994 |
Molecular Weight | 440.86 |
Formula | C21H18ClFN6O2 |
Cas No. | 1453848-26-4 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | Ethanol: 81 mg/mL (183.7 mM) DMSO: 81 mg/mL (183.7 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
Ethanol/DMSO
|
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.