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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $197 | In Stock | |
5 mg | $446 | In Stock | |
10 mg | $718 | In Stock | |
25 mg | $1,450 | In Stock | |
50 mg | $1,980 | In Stock |
Description | RH1 (NSC 697726) is a bioreductive anticancer compound that exhibits dose-dependent biphasic effects in vitro, inducing apoptosis at higher doses and senescence at lower doses. |
In vitro | RH1 causes apoptosis in NQ16 cells in a time- and concentration-dependent manner. Treatment of NQ16 cells with RH1 (50 and 100 nM) for 60 and 120 minutes resulted in a significant (p< 0.05) increase in cross-linked DNA [1]. |
In vivo | RH1 exhibited dose-dependent antitumor activity against NQ16 tumors grown in thymus-free mice. A small dose of RH1 (0.1 mg/kg) also resulted in a significant reduction in tumor size in treated mice compared to controls. Treatment of mice with NQ16 tumors with RH1 (0.4 mg/kg and 0.2 mg/kg) resulted in a significant reduction in tumor size between the treated and control groups as early as 5 days after the end of the treatment period [2]. |
Alias | NSC 697726 |
Molecular Weight | 234.25 |
Formula | C12H14N2O3 |
Cas No. | 221635-42-3 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | ||||||||||
Solubility Information | DMSO: 1 mg/mL (4.26 mM), Sonication and heating are recommended. | ||||||||||
Solution Preparation Table | |||||||||||
DMSO
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