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Rineterkib

Rineterkib
Rineterkib (ERK-IN-1) is an inhibitor of RAF and ERK1/2 activating mutations in the MAPK pathway.
Catalog No. T11224Cas No. 1715025-32-3
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Purity:98.4%
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Rineterkib

Catalog No. T11224Cas No. 1715025-32-3

Rineterkib (ERK-IN-1) is an inhibitor of RAF and ERK1/2 activating mutations in the MAPK pathway.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
1 mg$96In Stock
5 mg$198In Stock
10 mg$372In Stock
25 mg$629In Stock
50 mg$896In Stock
100 mg$1,220In Stock
1 mL x 10 mM (in DMSO)$262In Stock
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Product Introduction

Bioactivity
Description
Rineterkib (ERK-IN-1) is an inhibitor of RAF and ERK1/2 activating mutations in the MAPK pathway.
In vivo
ERK-IN-1 (50, 75 mg/kg, p.o., qd/q2d, 27 days) treatment significantly reduces the tumor volume in the Calu-6 human NSCLC subcutaneous tumor xenograft model in mice.
AliasERK-IN-1
Chemical Properties
Molecular Weight578.42
FormulaC26H27BrF3N5O2
Cas No.1715025-32-3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 60 mg/ml (103.73 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.7288 mL8.6442 mL17.2885 mL86.4424 mL
5 mM0.3458 mL1.7288 mL3.4577 mL17.2885 mL
10 mM0.1729 mL0.8644 mL1.7288 mL8.6442 mL
20 mM0.0864 mL0.4322 mL0.8644 mL4.3221 mL
50 mM0.0346 mL0.1729 mL0.3458 mL1.7288 mL
100 mM0.0173 mL0.0864 mL0.1729 mL0.8644 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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