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SB-435495

Catalog No. T75255Cas No. 304694-39-1

SB-435495 is an orally active, selective and potent Lp-PLA2 inhibitor (IC50: 0.06 nM) for the study of autoimmune uveitis and atherosclerosis.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Pack Size	Price	Availability
1 mg	$52	In Stock
2 mg	$74	In Stock
5 mg	$123	In Stock
10 mg	$198	In Stock
25 mg	$455	In Stock
50 mg	$745	In Stock
100 mg	$1,180	In Stock

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Product Introduction

Bioactivity

Description	SB-435495 is an orally active, selective and potent Lp-PLA2 inhibitor (IC50: 0.06 nM) for the study of autoimmune uveitis and atherosclerosis.
Alias	SB435495, SB 435495

Chemical Properties

Molecular Weight	720.82
Formula	C38H40F4N6O2S
Cas No.	304694-39-1

Storage & Solubility Information

Storage

store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 80 mg/mL (110.98 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.3873 mL	6.9365 mL	13.8731 mL	69.3654 mL
5 mM	0.2775 mL	1.3873 mL	2.7746 mL	13.8731 mL
10 mM	0.1387 mL	0.6937 mL	1.3873 mL	6.9365 mL
20 mM	0.0694 mL	0.3468 mL	0.6937 mL	3.4683 mL
50 mM	0.0277 mL	0.1387 mL	0.2775 mL	1.3873 mL
100 mM	0.0139 mL	0.0694 mL	0.1387 mL	0.6937 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc