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SB-435495
Catalog No. T75255Cas No. 304694-39-1
Alias SB435495, SB 435495
SB-435495 is an orally active, selective and potent Lp-PLA2 inhibitor (IC50 of 0.06 nM) for the study of autoimmune uveitis and atherosclerosis.
SB-435495
Catalog No. T75255Alias SB435495, SB 435495Cas No. 304694-39-1
SB-435495 is an orally active, selective and potent Lp-PLA2 inhibitor (IC50 of 0.06 nM) for the study of autoimmune uveitis and atherosclerosis.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $52 | In Stock | |
| 2 mg | $74 | In Stock | |
| 5 mg | $123 | In Stock | |
| 10 mg | $198 | In Stock | |
| 25 mg | $455 | In Stock | |
| 50 mg | $745 | In Stock | |
| 100 mg | $1,180 | In Stock |
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Purity:≥98%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | SB-435495 is an orally active, selective and potent Lp-PLA2 inhibitor (IC50 of 0.06 nM) for the study of autoimmune uveitis and atherosclerosis. |
| In vitro | SB-435495 inhibits CYP450 3A4 with an IC50 of 10 μM and a membrane permeability of 0.017 cm/h[1]; SB-435495 (5 μM; 24 h) significantly inhibits the expression of Lp-PLA2 protein and simultaneously increases oxLDL-exposed HUVECs. Medium expression levels of AMPKα and phospho-AMPKα (T172); SB-435495 (5 μM; 24-72 h) significantly increased cell viability and NO expression and significantly decreased ET-1 expression in oxLDL-exposed HUVECs[2] . |
| In vivo | SB-435495 (10 mg/kg; p.o.; once) inhibits plasma Lp-PLA2 in WHHL rabbit [1].
SB-435495 (10 mg/kg; i.p.; daily for 28 days) effectively inhibits blood retinal barrier (BRB) disruption in Streptozotocin diabetic Brown Norway rats [3]. |
| Alias | SB435495, SB 435495 |
| Molecular Weight | 720.82 |
| Formula | C38H40F4N6O2S |
| Cas No. | 304694-39-1 |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80 mg/mL (110.98 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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