Shopping Cart

Remove All

Your shopping cart is currently empty

SBC-115076

Select Batch

Purity:99.89%

Resource Download

COA HPLC HNMR

SBC-115076

Catalog No. T2626Cas No. 489415-96-5

SBC-115076 is a potent extracellular proprotein convertase subtilisin kexin type 9 (PCSK9) antagonist.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Pack Size	Price	Availability
1 mg	$34	In Stock
2 mg	$48	In Stock
5 mg	$77	In Stock
10 mg	$101	In Stock
25 mg	$190	In Stock
50 mg	$343	In Stock
100 mg	$531	In Stock
500 mg	$1,180	In Stock
1 mL x 10 mM (in DMSO)	$84	In Stock

Bulk & Custom

Add to Cart

Questions

Related Compound Libraries of "SBC-115076"

Product Introduction

Bioactivity

Description	SBC-115076 is a potent extracellular proprotein convertase subtilisin kexin type 9 (PCSK9) antagonist.
In vitro	In HepG2 cells, SBC-115076 increases the uptake of Fluorescent Dil-LDL. [1]
In vivo	In mice that are fed high fat diet, SBC-115076 (8 mg/kg) lowers cholesterol levels by 32%. [1]
Alias	SBC115076

Chemical Properties

Molecular Weight	527.61
Formula	C31H33N3O5
Cas No.	489415-96-5

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 93 mg/mL (176.3 mM)

H2O: < 1 mg/mL (insoluble or slightly soluble)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8953 mL	9.4767 mL	18.9534 mL	94.7670 mL
5 mM	0.3791 mL	1.8953 mL	3.7907 mL	18.9534 mL
10 mM	0.1895 mL	0.9477 mL	1.8953 mL	9.4767 mL
20 mM	0.0948 mL	0.4738 mL	0.9477 mL	4.7383 mL
50 mM	0.0379 mL	0.1895 mL	0.3791 mL	1.8953 mL
100 mM	0.0190 mL	0.0948 mL	0.1895 mL	0.9477 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc