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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $132 | In Stock | |
5 mg | $332 | In Stock | |
10 mg | $487 | In Stock | |
25 mg | $763 | In Stock | |
50 mg | $998 | In Stock | |
1 mL x 10 mM (in DMSO) | $552 | In Stock |
Description | Schinifoline is a quinolone derivative extracted from Zanthoxylum schinifolium Sieb with cytotoxic activity that promotes radiosensitization of cancer cells, affects the cell cycle and apoptosis. |
In vitro | This work aimed to investigate the radiosensitizing effect of Schinifoline (SF) on A549 cells. The cell viability results indicated cytotoxicity of SF on A549 cells, with IC50 values of 33.7 ± 2.4, 21.9 ± 1.9 and 16.8 ± 2.2 μg/mL, respectively, after 6, 12, 24 h treatment with different concentrations, and the 10% or 20% IC50 concentration during 12 h was applied in later experiments. The results of cell proliferative inhibition and clonogenic assay showed that SF enhanced the radiosensitivity of A549 cells when applied before 60Co γ-irradiation and this effect was mainly time and concentration dependent. The flow cytometric data indicated that SF treatment before the irradiation increased the G2/M phase, thus improving the radiosensitivity of A549, leading to cell apoptosis.[1] |
Molecular Weight | 257.37 |
Formula | C17H23NO |
Cas No. | 80554-58-1 |
Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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