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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $970 | In Stock |
Description | SD-36 is a selective and efficient STAT3 protein degrader (Kd=~50 nM) with antitumor activity that promotes growth inhibition and induces apoptosis by inhibiting Mcl-1 in gliomas.SD-36 inhibits the transcriptional activity of STAT3. |
In vitro | In MOLM-16, DEL, Karpas-299, KI-JK, SU-DHL-I, SUP-M2 cell lines, SD-36 ( 0.005, 0.05, 0.5, 5 μM ; 4 days ) can Demonstrated potent activity ( IC50 < 2 μM ) in those cell lines[1]. |
In vivo | In SCID female mice ( MOLM-16 xenograft model ), SD-36 ( 25,50,100 mg / kg ; i.v. ; at either 100 mg / kg weekly or 50 mg / kg twice weekly for 4 weeks induced complete tumor regression. At either 100 mg / kg weekly or 50 mg / kg twice weekly for 4 weeks induced complete tumor regression[1]. |
Molecular Weight | 1158.15 |
Formula | C59H62F2N9O12P |
Cas No. | 2429877-44-9 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||
Solubility Information | DMSO: 30 mg/mL (25.90 mM) | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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