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Selurampanel
🥰Excellent
Catalog No. T34609Cas No. 912574-69-7
Alias BGG-492, BGG492, BGG 492
Selurampanel (BGG492) is an orally active and selective competitive AMPA glutamate receptor antagonist, a quinazoline-dione sulfonamide. selurampanel is used in the study of epilepsy, migraine and tinnitus.
Selurampanel
🥰Excellent
Purity: 99.41%
Catalog No. T34609Alias BGG-492, BGG492, BGG 492Cas No. 912574-69-7
Selurampanel (BGG492) is an orally active and selective competitive AMPA glutamate receptor antagonist, a quinazoline-dione sulfonamide. selurampanel is used in the study of epilepsy, migraine and tinnitus.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $189 | In Stock | |
| 5 mg | $449 | In Stock | |
| 10 mg | $646 | In Stock | |
| 25 mg | $998 | In Stock | |
| 50 mg | $1,330 | In Stock | |
| 100 mg | $1,790 | In Stock | |
| 500 mg | $3,630 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $469 | In Stock |
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Purity:99.41%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Selurampanel (BGG492) is an orally active and selective competitive AMPA glutamate receptor antagonist, a quinazoline-dione sulfonamide. selurampanel is used in the study of epilepsy, migraine and tinnitus. |
| Targets&IC50 | AMPA:190 nM |
| In vivo | Selurampanel (3 mg/kg i.v.) a mouse plasma half-life of 3.3 h is determined, with a moderate volume of distribution (Vdss=1.3 L/kg) and a low clearance of 5.4 mL/minâ–ªkg.[5] Selurampanel potently and dose-dependently antagonizes maximal electroshock seizure-induced generalized tonic-clonic seizures in mice with an ED50 value around 7 mg/kg after 1 h pre-treatment.[5] |
| Alias | BGG-492, BGG492, BGG 492 |
| Molecular Weight | 377.42 |
| Formula | C16H19N5O4S |
| Cas No. | 912574-69-7 |
| Smiles | C(C)(C)C1=C(C=C2C(=C1)NC(=O)N(NS(C)(=O)=O)C2=O)C=3N(C)N=CC3 |
| Relative Density. | 1.49 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 27.5 mg/mL (72.86 mM)  | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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